Medical mystery: man met aneurysma van de aorta en terugkerende rugpijn

Medical mystery: man met aneurysma van de aorta en terugkerende rugpijn

Een 66-jarige man met in de voorgeschiedenis een monoclonale gammopathie van onbepaalde betekenis (IgG-kappa) wordt verwezen wegens rugpijn. In het verleden werd hij reeds geëvalueerd omwille van pijn in de kuiten en aan de achillespezen. Onderzoek wees toen op de aanwezigheid van HLA-B27 met een positieve familiale anamnese van psoriasis artritis, maar klinisch en echografisch werden geen bijzonderheden vastgesteld en de botscan was negatief. Hij maakt regelmatig avontuurlijke reizen naar verschillende continenten en doet intensief aan wielersport. Als medicatie neemt hij enkel acetylsalicylzuur en solifenacine.

“Antibodies against vascular endothelial growth factor decrease hyperfiltration and albuminuria in experimental diabetes”

the XXXVI Congress of the European Renal Association, Madrid
05-08/09/1999

”Endothelial dysfunction in diabetes: a role for folate?”,

Homocysteine Working Group, Nijmegen
28/10/1999

“Impaired endothelium-derived hyperpolarizing factor (EDHF) – mediated renal vasodilatory response in diabetes: restoration with folate”

the 32nd Annual Meeting of the American Society of Nephrology, Miami
05-08/11/1999

“Impaired endothelium-derived hyperpolarizing factor (EDHF) – mediated renal vasodilatory response in diabetes: restoration with folate”

the 32nd Annual Meeting of the American Society of Nephrology, Miami
05-08/11/1999

“The diabetic rat model to study high glucose-induced peritoneal membrane changes using the videomicroscope system”

PD solutions for the 21st century: experimental and clinical models for evaluation of new PD solutions, Brussels
25/01/2000

”Diabetes as a model to study the effects of high dialysate glucose levels on peritoneal structure and function”

4th European Peritoneal Dialysis Meeting, 3rd International Meeting on Aminal Models in Peritoneal Dialysis, Madrid
15-18/04/2000

“Hyperpermeability of the peritoneal membrane in diabetes: role of VEGF”

4th European Peritoneal Dialysis Meeting, Madrid
15-18/04/2000

”Role of vascular endothelial growth factor in diabetes”

Symposium Renal Microcirculation, Heidelberg
05/07/2000

“Endothelial dysfunction in the diabetic renal microcirculation: restoration with folate”

XXXVII Congress of the European Renal Association, First combined congres with European Kidney Research Association, Nice
17-20/09/2000

“Vascular dysfunction in diabetes”

Dresden
15/11/2000

“Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes”

Wetenschappelijke Vergadering van de Nederlandse Vereniging voor Nefrologie, Nijmegen
18/11/2000

“Endothelial dysfunction in diabetes”,

Aarhus Kommunehospital, Aarhus
11/01/2001

“Biocompatibility Issues in Peritoneal Dialysis”

5th Course of the Dialysis Academy, Gent
01/04/2001

“How do peritoneal dialysis fluids influence peritoneal vascular reactivity and neoangiogenesis ?”

IX Congress of the International Society for Peritoneal Dialysis, Montréal
26-29/06/2001

“The effects of heparin administration in an animal model of chronic dialysate exposure”

IX Congress of the International Society for Peritoneal Dialysis, 4th International Meeting on Aminal Models in Peritoneal Dialysis, Montréal
26-29/06/2001

“Effects of connexin-mimetic peptides on endothelium-derived hyperpolarizing factor (EDHF) – mediated renal vasodilatation, basal renal blood flow and blood pressure”.

XXXVIII Congress of the European Renal Association, Wenen
24-27/06/2001

“Role of glucose degradation products in PD”

7th Course of the Dialysis Academy, Gent
24/03/2002

“Intravital microscopy to evaluate functional properties of standard and pH neutral dialysis solutions”

Fifth European Peritoneal Dialysis Conference, Brussel
05/05/2002

“Mechanisms of glucose toxicity to the peritoneal membrane”

35th Annual Meeting of the American Society of Nephrology, Philadelphia
03/11/2002

“Neoangiogenesis in the peritoneal membrane”

World Congress of Nephrology, Berlin
10/06/2003

“The effect of diabetes on the peritoneal membrane: experimental results and clinical correlations”

36th Annual Meeting of the American Society of Nephrology, San Diego
14-17/11/2003

“RAGE in the peritoneum”

First Joint Meeting of the International Society of Peritoneal Dialysis and the European Peritoneal Dialysis Meeting, Amsterdam
28/08/2004

“On VEGF – the most important growth factor in PD membrane alterations”,

First Joint Meeting of the International Society of Peritoneal Dialysis and the European Peritoneal Dialysis Meeting, Amsterdam
29/08/2004

“Controlling angiogenesis”

7th European Peritoneal Dialysis Meeting, Praag
15-18/10/2005

“Difficulties in setting up an animal model of peritonitis”,

ANIMOD Meeting, 7th European Peritoneal Dialysis Meeting, Praag
15-18/10/2005

“Peritoneal and extraperitoneal effects of GDPs and AGEs”

The 11th Congress of the International Society of Peritoneal Dialysis, Hong-Kong
25-29/08/2006

“Diagnosis and treatment of CAD in ESRD: Can we do better?”

9th European Peritoneal Dialysis Meeting, Strassbourg
09-12/10/2009

“VEGF in renal pathophysiology”

Conference on Renal Safety, Zurich
27/09/2010

“New insights in pharmacokinetics and pharmacodynamics of antibiotics: implications for the treatment of peritonitis “

49th ERA-EDTA Congress, Parijs
24/05/2012

“Hemodialysis, do we need individualized treatment prescriptions ?”

2nd International Renal Meeting in Sardinia, Cagliari
30/04/2013

“Vancomycin: the tale of the vanquisher and the Pyrrhic victory”

11th European Peritoneal Dialysis Meeting, Maastricht
12/10/2013

“Vitamin K antagonists in dialysis: navigating between Scylla and Charybdis”

First International Renal Conference, Brugge
21/03/2014

“The evidence for intensive dialysis: frequent and prolonged dialysis, hemodiafiltration”, “Vitamin K and vascular calcifications”, and “Hemodialysis catheters: does design matter ?”

Simposio Fronteras 2014, Santiago de Chili
05-07/05/2014

“Old and new antibiotics in dialysis”

3rd International Renal Meeting in Sardinia, Cagliari
02/05/2015

“Oral anticoagulation in dialysis patients: challenges and opportunities”

Cardiology Divisional Grand Rounds, Mazankowski Alberta Heart Institute, Edmonton
27/05/2015

“Oral anticoagulation in dialysis patients”, and “The use of vancomycin in CKD, hemodialysis and peritoneal dialysis”

Srinagar
03/09/2015

“Oral anticoagulation in hemodialysis: new insights”

First Mayo Clinic Nephrology Meeting in Argentina, Buenos Aires
07/05/2016

“Should we use vitamin K antagonists in hemodialysis patients?”,

Trondheim Renal Research Group/Norwegian Society of Nephrology, Tröndheim
02/09/2016

“Oral anticoagulation in dialysis: alternatives to warfarin.”

Congres of the Iranian Society of Nephrology, Shiraz
19/05/2017

“Oral anticoagulation in hemodialysis patients: challenges and opportunities”

34th Biennal Congres of the Nordic Society of Nephrology, Malmö
20-23/09/2017

“An update in peritoneal dialysis”

Nephro Update Europe, Vienna
06-07/10/2017

“Infectious complications of peritoneal dialysis”

Second International Renal Conference, Brugge
16-17/03/2018

“Serology-based approach to membranous nephropathy”

Third International Conference on Membranous Nephropathy, Bergamo
04-05/05/2018

“What is new in peritoneal dialysis?” and “Infectious complications in peritoneal dialysis”

Mayo Clinic Meeting, Asuncion, Paraguay
20-21/09/2018

“An update in peritoneal dialysis”

Nephro Update Europe, Boedapest
05-06/10/2018

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Other consequences from monoclonal immunoglobulins/fragments. Membranoproliferative glomerulonephritis and acquired Fanconi syndrome.

In: The Oxford Textbook of Clinical Nephrology.
» http://www.ncbi.nlm.nih.gov/pubmed/

Membranoproliferative glomerulonephritis and cryoglobulinemic glomerulonephritis.

In: Comprehensive Clinical Nephrology, 6th Edition. Edited by John Feehally, Rick Johnson, Jürgen Floege, Marcello Tonelli.
» http://www.ncbi.nlm.nih.gov/pubmed/

Membranous nephropathy.

In: National Kidney Foundation’s Primer on Kidney Diseases, 7th Edition. Edited by Scott Gilbert, Daniel Weiner, Andrew Bomback, Mark Perazella, Marcello Tonelli, pp. 188-197. ISBN: 978-0-323-47794-9
» http://www.ncbi.nlm.nih.gov/pubmed/

Membranoproliferative glomerulonephritis.

In: Current Progress in Nephrology. Edited by Claudio Ponticelli and R Kasi Visweswaran, pp. 57-78. ISBN: 978-93-83989-19-5
» http://www.ncbi.nlm.nih.gov/pubmed/

Indications to start kidney replacement therapy.

In: Management of acute kidney problems. Edited by A Jorres, C Ronco and Kellum, pp 471-479. ISBN: 978-3-540-69413-7
» http://www.ncbi.nlm.nih.gov/pubmed/

The peritoneal microcirculation in peritoneal dialysis.

In: Textbook of Peritoneal Dialysis, 3rd Edition. Edited by R Gokal, R Khanna, RT Krediet and KD Nolph, pp 51-71. ISBN 978-0-387-78939-2
» http://www.ncbi.nlm.nih.gov/pubmed/

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference.

Kidney Int 2017;91:539-551.
01/01/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: Results of a proteomic analysis.

Nephrol Dial Transplant 2017;32(suppl_1):i139-i145.
01/01/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Interstitial immunostaining and renal outcomes in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

Am J Nephrol 2017;46:231-238.
01/01/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

The incidence of primary versus secondary focal and segmental glomerulosclerosis: a clinicopathological study.

Mayo Clin Proc 2017;92:1772-1781.
01/01/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Mayo Clinic/ Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of Glomerulonephritis.

J Am Soc Nephrol 2016; 27: 1278-87.
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials.

Clin Kidney J 2016; 9: 273-279.
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Vitamin K antagonists for stroke prevention in hemodialysis patients with atrial fibrillation: a meta-analysis.

Am Heart J 2016; 184: 37-46.
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Hemodialysis catheter design and catheter performance: a randomized controlled trial.

Am J Kidney Dis 2014; 64: 902-8. Erratum in Am J Kidney Dis 2015; 65: 810.
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

In reply to “Hemodialysis catheters: which design is more cost-effective? And “Use of an uncensored primary outcome in a catheter design trial”.

Am J Kidney Dis 2015; 66: 171.
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Glomerular disease caused by dysregulation of the complement alternative pathway: an etiologic approach.

J Am Soc Nephrol 2015; 26: 2917-2929.
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Measurement of pulse wave velocity, augmentation index and central pulse pressure in atrial fibrillation: a proof of concept study.

J Am Soc Hypertens 2018; 12: 627-632.
01/01/2018

» http://www.ncbi.nlm.nih.gov/pubmed/

Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia.

Biochim Biophys Acta 2013; 1832: 1708-14.
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

The pharmacokinetics and pharmacodynamics of vancomycin in clinical practice: evidence and uncertainties.

J Antimicrob Chemother 2013; 68: 743-8.
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia.

Biochim Biophys Acta 2013; 1832: 1708-14.
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Successful treatment of renal AA amyloidosis in familial Mediterranean fever with pegylated -2a interferon.

Clin Nephrol 2011; 75 (Suppl 1): S1-S3.
01/01/2011

» http://www.ncbi.nlm.nih.gov/pubmed/

Implementation of a dose calculator for vancomycin to achieve target through levels of 15-20 mg:ml in persons undergoing hemodialysis.

Clin Inf Dis 2011; 53: 124-129.
01/01/2011

» http://www.ncbi.nlm.nih.gov/pubmed/

Comparison of the prognostic value of dipyridamole and dobutamine myocardial perfusion scintigraphy in end-stage renal disease.

Kidney Int 2009; 76: 428-436.
01/01/2009

» http://www.ncbi.nlm.nih.gov/pubmed/

Guanidinocompounds after creatine supplementation in renal failure patients and their relation to inflammatory status.

Nephrol Dial Transplant 2008; 23: 1330-1335.
01/01/2008

» http://www.ncbi.nlm.nih.gov/pubmed/

Autologous transplantation of bone marrow mononuclear cells for limb ischemia in a Caucasian population with atherosclerosis obliterans.

J Intern Med 2008; 263: 395-403.
01/01/2008

» http://www.ncbi.nlm.nih.gov/pubmed/

Decreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: An in vivo study.

J Hepatol 2007; 46: 804-815.
01/01/2007

» http://www.ncbi.nlm.nih.gov/pubmed/

A neutralizing VEGF antibody prevents glomerular hypertrophy in a model of obese type 2 diabetes, the Zucker diabetic fatty rat.

Nephrol Dial Transplant 2006; 21: 324-329.
01/01/2006

» http://www.ncbi.nlm.nih.gov/pubmed/

Activation of genes inducing cell-cycle arrest and of increased DNA repair in the hearts of rats with early streptozotocin-induced diabetes mellitus.

Med Sci Monit 2006; 12: BR68-74.
01/01/2006

» http://www.ncbi.nlm.nih.gov/pubmed/

RAGE-induced myofibroblast transdifferentiation of mesothelial cells contributes to peritoneal fibrosis in uremia.

Nephrol Dial Transplant 2006; 21: 2549-2555.
01/01/2006

» http://www.ncbi.nlm.nih.gov/pubmed/

Increased angiogenesis and permeability in the mesenteric microvasculature of rats with cirrhosis and portal hypertension: an in vivo study.

Liver Int 2006; 26: 889-898.
01/01/2006

» http://www.ncbi.nlm.nih.gov/pubmed/

Current recommendations for diagnosis and management of polyoma BK virus nephropathy in renal transplant recipients.

Nephrol Dial Transplant 2006; 21: 3364-3367.
01/01/2006

» http://www.ncbi.nlm.nih.gov/pubmed/

Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes.

Horm Metab Res 2005; 37: 21-25.
01/01/2005

» http://www.ncbi.nlm.nih.gov/pubmed/

Benefits of switching from a conventional to a low-GDP bicarbonate/lactate-buffered peritoneal dialysis solution in a rat model.

Kidney Int 2005; 76: 1559-1565.
01/01/2005

» http://www.ncbi.nlm.nih.gov/pubmed/

Management of therapy-resistant systemic lupus erythematosus with rituximab: report of a case and review of the literature.

Acta Clin Belg 2005; 60: 102-105.
01/01/2005

» http://www.ncbi.nlm.nih.gov/pubmed/

Effects of new peritoneal dialysis solutions on leukocyte recruitment in the rat peritoneal membrane.

Nephron Exp Nephrol 2005; 101: e139-e145.
01/01/2005

» http://www.ncbi.nlm.nih.gov/pubmed/

From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines.

Endocrine Rev 2004; 25: 971-1010.
01/01/2004

» http://www.ncbi.nlm.nih.gov/pubmed/

The role of hyperhomocysteinemia in relation to nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation.

Cell Mol Biol 2004; 50: 911-916.
01/01/2004

» http://www.ncbi.nlm.nih.gov/pubmed/

Vascular hyporesponsiveness in the mesenteric artery of anaesthetized rats with cirrhosis and portal hypertension: an in-vivo study.

Eur J Gastroenterol Hepatol 2004; 16: 139-145.
01/01/2004

» http://www.ncbi.nlm.nih.gov/pubmed/

Systemic and splanchnic haemodynamic effects of sildenafil in an in vivo animal model of cirrhosis: support for a risk in cirrhotic patients.

Liver Int 2004; 24: 63-68.
01/01/2004

» http://www.ncbi.nlm.nih.gov/pubmed/

Endothelium-derived hyperpolarizing factor – mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.

Circulation 2004; 109: 2331-2336.
01/01/2004

» http://www.ncbi.nlm.nih.gov/pubmed/

The statement that folate supraphysiological levels in uremic patients do not cause harm should not go unchallenged.

Kidney Int 2003; 63 :771-773.
01/01/2003

» http://www.ncbi.nlm.nih.gov/pubmed/

Recent concepts in the molecular biology of the peritoneal membrane – Implications for more biocompatible dialysis solutions.

Blood Purif 2003; 21: 14-23.
01/01/2003

» http://www.ncbi.nlm.nih.gov/pubmed/

Effects of conventional and new peritoneal dialysis solutions on leukocyte recruitment in the microcirculation of the rat peritoneal membrane.

J Am Soc Nephrol 2003; 14: 1296-1306.
01/01/2003

» http://www.ncbi.nlm.nih.gov/pubmed/

Inhibition of AGE-RAGE interaction prevents hyperglycemia-induced fibrosis of the peritoneal membrane.

J Am Soc Nephrol 2003; 14: 2109-2118.
01/01/2003

» http://www.ncbi.nlm.nih.gov/pubmed/

Effects of connexin-mimetic peptides on nitric oxide synthase- and cyclooxygenase-independent renal vasodilatation, basal renal blood flow and blood pressure.

Kidney Int 2002; 61: 177-185.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Hemodynamic effects of conventional and new peritoneal dialysis solutions on the microcirculation of the rat peritoneal membrane. Role of acidity, buffer choice, glucose concentration and glucose degradation products.

J Am Soc Nephrol 2002; 13: 480-489.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Is folate a promising agent in the prevention and treatment of cardiovascular disease in patients with renal failure?

Kidney Int 2002; 61: 1199-1209.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Compensatory glomerular hypertrophy following unilateral nephrectomy is strictly VEGF dependent.

Am J Physiol Endocrinol Metab 2002; 283: E362-366.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Comparison of the radioiodinated serum albumin (RISA) dilution technique with direct volumetric measurements in animal models of peritoneal dialysis.

Perit Dial Int 2002; 22: 316-322.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Amelioration of long-term renal changes in obese type 2 diabetic mice with a neutralizing vascular endothelial growth factor (VEGF)-antibody.

Diabetes 2002; 51: 3090-3094.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Increased leukocyte rolling in newly formed mesenteric vessels in the rat peritoneal membrane during peritoneal dialysis.

Perit Dial Int 2002; 22: 655-662.
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Connexin-mimetic peptides: Influence on nitric oxide synthase- and cyclooxygenase-independent renal vasodilatation, basal renal blood flow and blood pressure in the rat.

In: EDHF 2002. Edited by PM VANHOUTTE, pp 78-86. ISBN 0-415-30853-4
01/01/2002

» http://www.ncbi.nlm.nih.gov/pubmed/

Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes.

J Am Soc Nephrol 2001; 12: 993-1000.
01/01/2001

» http://www.ncbi.nlm.nih.gov/pubmed/

Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane.

J Am Soc Nephrol 2001; 12: 1734-1741.
01/01/2001

» http://www.ncbi.nlm.nih.gov/pubmed/

Folate restores the NO synthase- and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes.

In: EDHF 2000. Edited by PM VANHOUTTE, pp 360-369. ISBN 0-415-26904-0
01/01/2000

» http://www.ncbi.nlm.nih.gov/pubmed/

The impaired renal vasodilator response attributed to endothelium-derived hyperpolarizing factor in streptozotocin-induced diabetic rats is restored by 5-methyltetrahydrofolate.

Diabetologia 2000; 43: 1116-1125.
01/01/2000

» http://www.ncbi.nlm.nih.gov/pubmed/

Acute renal failure in natural disasters.

In: Acute renal failure: a companion to Brenner & Rector’s the kidney. Edited by B MOLITORIS, W FINN, pp 236-245. ISBN 0-7216-9174-9
01/01/1999

» http://www.ncbi.nlm.nih.gov/pubmed/

Continuous renal replacement therapies in sepsis: do they matter?

In: Yearbook of Intensive Care and Emergency Medicine 1999, Edited by JL VINCENT, pp 611-620. ISSN 0942-5381.
01/01/1999

» http://www.ncbi.nlm.nih.gov/pubmed/

The role of selectins in glomerular leukocyte adhesion in rat anti-glomerular basement membrane glomerulonephritis.

J Am Soc Nephrol 1999; 10: 2510-2517.
01/01/1999

» http://www.ncbi.nlm.nih.gov/pubmed/

Severe acute renal failure due to bromate intoxication: report of a case and discussion of management guidelines based on a review of the literature.

Nephrol Dial Transplant 1997; 12: 204-209.
01/01/1997

» http://www.ncbi.nlm.nih.gov/pubmed/

Influence of vasoactive intestinal polypeptide and NG-nitro-L-argininemethylester on cholinergic neurotransmission in the rat gastric fundus.

Eur J Pharmacol 1992; 221: 235-242.
01/01/1992

» http://www.ncbi.nlm.nih.gov/pubmed/
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