Doorgedreven parkinsonbegeleiding

Doorgedreven parkinsonbegeleiding

De ziekte van Parkinson is onvoorspelbaar en veroorzaakt heel uiteenlopende beperkingen en obstakels. Genezing is vooralsnog niet aan de orde, maar de juiste medische en paramedische begeleiding kan de patiënt hulpmiddelen aanreiken om een optimale levenskwaliteit te verzekeren. Vandaar de oprichting van een gloednieuw parkinsonzorgprogramma in het AZ Sint-Jan Brugge-Oostende AV.

Hypothermie als behandeling voor acute ischemische beroerte

Hypothermie als behandeling voor acute ischemische beroerte

Elk jaar worden ongeveer 19.000 Belgen getroffen door een beroerte. In het merendeel van de gevallen gaat het om een ischemische beroerte. De morbiditeit, mortaliteit en het kostenplaatje zijn hoog. Naast de hemicraniëctomie op de “stroke unit” bij een maligne media-infarct en het toedienen van aspirine is de intraveneuze trombolyse een van de bewezen effectieve behandelingen in de acute fase. Helaas krijgt uiteindelijk slechts 5 tot 15% van alle patiënten intraveneus rtPA (recombinant weefselplasminogeenactivator) toegediend, gezien het beperkte tijdsvenster waarbinnen trombolyse kan worden toegepast: tot 4,5 uur na het ontstaan van de symptomen.

Medical mystery: abdominale klachten en krachtsvermindering (VIDEO)

Medical mystery: abdominale klachten en krachtsvermindering (VIDEO)

Een 68-jarige man wordt opgenomen op de afdeling Maag-, Darm- en Leverziekten wegens verminderde eetlust, een opgezette buik, wisselende abdominale krampen en constipatie sinds een maand. ’s Ochtends ondervindt hij bovendien geregeld een veranderd “sponsachtig” gevoel ter hoogte van de buik. Bijkomend vermeldt hij een uitstralende pijn vanuit de heup naar de lies en later ook de lage rug. Sedert het begin van de klachten vermagerde hij een drietal kg en voelt hij zich vaak moe. Hij heeft geen koorts.

Diagnostische aanpak van patiënten met Mild Cognitive Impairment – Rol van de  multidisciplinaire geheugenkliniek

Diagnostische aanpak van patiënten met Mild Cognitive Impairment – Rol van de multidisciplinaire geheugenkliniek

Steeds meer patiënten worden verwezen voor diagnostiek en behandeling van lichte geheugenklachten. Hoewel de meeste patiënten met Mild Cognitive Impairment (MCI) een gunstige evolutie vertonen, ontwikkelt zich bij een significant aantal (18% per jaar) een dementie,doorgaans van het Alzheimer­type (AD). Bovendien toont post mortemonderzoek bij MCI­patiënten vaak pathologische kenmerken van AD, zoals neurofibrillaire tangles in de hippocampus en entorhinale cortex.

‘Alzheimer 2016: advances concerning diagnosis and treatment of Alzheimer’s disease and related disorders’.

Belgian Neurological Society and Belgian Dementia Council (BeDeCo)
10/12/2016

Predictive parameters for the effect of botulinum neurotoxin infiltrations in chronic migraine.

Brugge
01/01/2016

Botulinum toxin infiltrations for chronic migraine are efficacions and safe: the Bruges experience.

Brugge
01/01/2016

New treatment strategies in pediatric neurology.

Gent
24/04/2015

ee broers met progressieve ataxie na 20-jarige leeftijd t.g.v. een recent ontdekte genetische aandoening.

UZ Gent
26/03/2015

Clues to Molecular Genetic Diagnosis in Malformations of Cortical Development.

Brugge
30/01/2015

Botulinum toxin infiltrations for chronic migraine are efficacious and safe : the Bruges experience.

Gent
01/10/2014

Predictive parameters for the effect of botulinum toxin infiltrations in chronic migraine.

Copenhagen
01/09/2014

Pathogenic mutations in the mitochondrial alanyl tRNA synthetase (AARS2) gene of an adult patient.

Finland
15-19/06/2014

The search for the unknown gene: from symptomatology to causative gene defect. Recent advances in neurogenetics, illustrated with practice examples.

AZ Sint-Jan te Brugge
21/02/2014

Development of an S-G2 micronucleus assay for the detection of in vitro chromosomal radiosensitivity in high-risk women subjected to early mammography screening for breast cancer.

Abstract on 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine" October 2013 , Crete, Greece.
10/2013

Round Table on sulthiame in childhood epilepsy.

10th European Paediatric Neurology Society Congress 2013 - 25-28 September 2013 – Brussels.
25-28/09/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Parallel session on Fetal and Neonatal Neurology.

10th European Paediatric Neurology Society Congress 2013 - 25-28 September 2013 – Brussels.
25-28/09/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Update Mitochondriale Aandoeningen.

Wetenschappelijke stafvergadering van de dienst neurologie van het AZ Sint-Jan te Brugge op vrijdag 29/3/2013.
29/03/2013

Normalisation of PET hypometabolism after treatment in NMDA-receptor antibody encephalitis.

Dublin
01/06/2012

Normalisation of PET hypometabolism after treatment in NMDA-receptor antibody encephalitis.

Berlin
01/05/2012

Normalisation of PET hypometabolism after treatment in NMDA-receptor antibody encephalitis.

Berlin
01/01/2012

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vivo: no evidence for a cell autonomous role of APP in neuronal differentiation.

Thessaloniki
01/03/2010

Neuronal differentiation of APP/APLP1/APLP2 triple knockout embryonic stem cells.

Chicago
01/07/2008

Neuronal differentiation of APP/APLP1/APLP2 triple knockout embryonic stem cells.

San Diego
01/11/2007

Neuronal cultures derived from mouse embryonic stem cells as models for neurodegenerative diseases.

Brussel
01/08/2007

Neuronal cultures derived from mouse embryonic stem cells as models for neurodegenerative diseases.

Atlanta
01/10/2006

Familial migraine with aura and partial epilepsy involving posterior brain regions caused by a mutation in SLC4A4, a sodium bicarbonate cotransporter gene.

Washington
01/10/2005

Screening for CLCN2 and GABRA1 Mutations in Juvenile Myoclonic Epilepsy Patients.

Miami
01/04/2005

Modifiers of the neuropathological phenotype and the classification of Creutzfeldt-Jakob Disease.

Helsinki
01/01/2002

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Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.

Neurology. 2016 Jun 7;86(23):2126-33. doi: 10.1212/WNL.0000000000002628.
01/06/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients.

Neurobiol Aging. 2013 Jun;34(6):1711.e1-5. DOI: 10.1016/j.neurobiolaging.2012.12.007
01/06/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.

Brain. 2016 Feb;139(Pt 2):452-67. doi: 10.1093/brain/awv358
01/02/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

MRI with intrathecal gadolinium to detect a CSF leak: feasibility and long term safety from an open label single centre cohort study.

Neurology 2016;86(Supp P4.113). (abstract)
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Characterizing absolute lymphocyte count profiles in dimethyl fumarate–treated patients with MS.

Neurology: clinical practice 2016;6(3):220-229
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

Neurology. 2015 Dec 15;85(24):2116-25. doi: 10.1212/WNL.0000000000002220.
15/12/20015

» http://www.ncbi.nlm.nih.gov/pubmed/

Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort.

Hum Mutat. 2015 Dec;36(12):1226-35. doi: 10.1002/humu.22908.
01/12/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

A 22-single nucleotide polymorphism Alzheimer’s disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

Alzheimers Dement. 2015 Dec;11(12):1452-60. doi: 10.1016/j.jalz.2015.02.013.
01/12/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.

Acta Neuropathol Commun. 2015 Nov 10;3:68. doi: 10.1186/s40478-015-0246-7.
10/11/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

C9orf72 repeat size correlation with onset age of disease, hypermethylation and transcriptional downregulation of the C9orf72 promoter.

Mol Psychiatry. 2015 Oct 20. doi: 10.1038/mp.2015.159
20/10/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Multiple nocardial abscesses of the brainstem and spinal cord: diagnosis after an open biopsy through a cervical partial central corporectomy.

Neurosurgery: Spine. 2015 Jun 19:1-4. [Epub ahead of print]
19/06/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Bing-Neel Syndrome: two unexpected cases and review of the literature.

J Neurol Sci. 2015 Jun 16. pii: S0022-510X(15)00367-6. doi: 10.1016/j.jns.2015.06.026. [Epub ahead of print]
16/06/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Clinical evidence for genetic anticipation in C9orf72 pedigrees.

Front. Neurosci. Published on 05 May 2015, doi:10.3389/conf.fnins.2015.89.00070
05/05/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Clinical utility and applicability of biomarker-based diagnostic criteria for Alzheimer’s disease: a BeDeCo survey.

Acta Neurologica Belgica 2015, jan 10
10/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

 Safety and Tolerability of Anti-LINGO1 Monoclonal Antibody BIIB033 in Acute Optic Neuritis: The RENEW Trial.

Neurology 2015;84(14):Supplement P7.203 (abstract)
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Evaluation of Comprehensive Alemtuzumab Infusion Guidance in Patients with Relapsing-remitting Multiple Sclerosis: EMERALD Study Design.

Neurology 2015;84(14):Supplement P7.283 (abstract)
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Efficacy Analysis of the Anti-LINGO-1 Monoclonal Antibody BIIB033 in Acute Optic Neuritis: The RENEW Trial.

Neurology 2015;84(14):Supplement P7.202 (abstract)
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Ethics and End of Life in the Neuro-ICU.

Bookchapter in: Neurointensive Care: A Clinical Guide to Patient Safety. K Shukri, A Wartenberg, T Abdelhak, Eds. Springer.
01/01/2015

» http://www.ncbi.nlm.nih.gov/pubmed/

Predictive parameters for the effect of botulinum toxin infiltrations in chronic migraine.

The Journal of Headache and Pain 2014, 15 (Suppl 1):M1 (18 September 2014)
18/09/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Botulinum toxin infiltrations for chronic migraine are efficacious and safe: the Bruges experience.

Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
13/07/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Autosomal recessive cerebellar ataxia of adult onset due to STUB1 mutations.

Neurology. 2014 May 13;82(19):1749-50. doi: 10.1212/WNL.0000000000000416. Epub 2014 Apr 9.
09/04/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Investigating the role of rare heterozygous TREM2 variants in Alzheimer’s disease and frontotemporal dementia.

Neurobiol Aging. 2014 Mar;35(3):726.e11-9. Epub 2013 Oct 9. DOI: 10.1016/j.neurobiolaging.2013.09.009.
01/03/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Safety and efficacy of natalizumab in Belgian multiple sclerosis patients: subgroup analysis of the natalizumab observational program.

Acta Neurol Belg 2014.
01/01/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Safety and efficacy of natalizumab in Belgian multiple sclerosis patients: subgroup analysis of the natalizumab observational program.

Acta Neurol Belg 2014;114(3):167-78.
01/01/2014

» http://www.ncbi.nlm.nih.gov/pubmed/

Investigating the role of rare heterozygous TREM2 variants in Alzheimer’s disease and frontotemporal dementia.

Neurobiol Aging. 2014 Mar;35(3):726.e11-9. Epub 2013 Oct 9
09/010/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Variant ataxia telangiectasia: clinical and molecular findings and evaluation of radiosensitive phenotypes in a patient and relatives.

Neuromolecular Med. 2013 Sep;15(3):447-57. doi: 10.1007/s12017-013-8231-4. Epub 2013 Apr 30.
15/09/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Anti-glycine receptor antibody mediated progressive encephalomyelitis with rigidity and myoclonus associated with breast cancer.

Case Rep Neurol Med. 2013;2013:589154.doi:10.1155/2013/589154.
2013/07/10

» http://www.ncbi.nlm.nih.gov/pubmed/

Phenotype and genotype in 101 males with X-linked creatine transporter deficiency.

J Med Genet. 2013 Jul;50(7):463-72. doi: 10.1136/jmedgenet-2013-101658. Epub 2013 May 3.
07/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients

34(6):1711.e1-5. doi: 10.1016/j.neurobiolaging.2012.12.007
01/06/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort

70(3):365-73. doi: 10.1001/2013.jamaneurol.181
01/03/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis.

Multiple Sclerosis and Related Disorders 2013;2(3):200-3.
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Pseudotumoral rebound of multiple sclerosis in a pregnant patient after stopping natalizumab.

Multiple Sclerosis and Related Disorders 2013. http://www.msard-journal.com/article/S2211-0348(13)00117-X/abstract
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Anti-Glycine receptor antibody mediated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) associated with breast cancer.

Case Reports in Medicine 2013. http://dx.doi.org/10.1155/2013/589154
01/01/2013

» http://www.ncbi.nlm.nih.gov/pubmed/

Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15963-8
01/09/2010

» http://www.ncbi.nlm.nih.gov/pubmed/

Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally In Vitro and In Vivo: Lack of Evidence for a Cell Autonomous Role of APP in Neuronal Differentiation.

Stem Cells 2010 Mar 31;28(3):399-406.
01/03/2010

» http://www.ncbi.nlm.nih.gov/pubmed/
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