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Discipline: Laboratoriumgeneeskunde

laboratorium geneeskunde

De dienst Laboratoriumgeneeskunde gaat voor ‘samen sterker’

Campus Sint-Jan en campus Henri Serruys houden er voortaan één gemeenschappelijke dienst Laboratoriumgeneeskunde op na. Een fusie die de dienstverlening…

Next Generation Sequencing

Overheidskader voor Next Generation Sequencing krijgt vorm

Het Next Generation Sequencing (NGS)-expertisenetwerk in het AZ Sint-Jan Brugge-Oostende AV is een feit. Dit opende de deur naar participatie…

Opsporing van Kingella kingae-DNA bij osteo-articulaire infecties bij kinderen

Bij kinderen komen osteo-articulaire infecties (OAI) zoals osteomyelitis, septische artritis en spondylodiscitis relatief weinig voor. Gezien een OAI tot ernstige…

Als eerste in Vlaanderen digitaal met orderaanvraagprocedure en transfusiemanagement

Van handhygiëne tot duidelijke en correcte communicatie, patiëntveiligheid is te allen tijde een topprioriteit binnen een ziekenhuis. Omdat onderzoek uitwees dat fouten in het labogebeuren voor 60% te wijten zijn aan misstappen in de preanalytische fase, digitaliseerde campus Henri Serruys als eerste ziekenhuis in Vlaanderen zowel zijn orderaanvraagprocedure als zijn transfusiemanagement.

Innovaties verruimen diagnostische mogelijkheden binnen de microbiologie

Dankzij de introductie van nieuwe moleculaire amplificatietechnieken en de MALDI-TOF massaspectrometer heeft de medische microbiologie de laatste jaren een enorme…

Lipoproteïnen van verschillende grootte en densiteit gescheiden na ultracentrifugatie

Dienst Laboratoriumgeneeskunde voortrekker in Europees cardiovasculair preventiebeleid

Op 25 en 26 september 2014 organiseerden de European Atherosclerosis Society (EAS) en de European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) hun eerste gemeenschappelijke symposium in het concertgebouw van Brugge, de “Atherosclerosis and Cardio-Endocrine Biomarkers Course”. Prof. dr. Michel Langlois trad op als voorzitter namens de Belgian Lipid Club en de dienst Laboratoriumgeneeskunde van het AZ Sint-Jan Brugge-Oostende AV. Internationale opinieleiders gaven er – voor een multidisciplinair publiek van endocrinologen, cardiologen, huisartsen, klinisch biologen en laboratoriumtechnologen – hun visie over nieuwe biomerkers voor het management van dyslipidemie en de preventie van atherosclerose en cardiovasculaire ziekte. Hierna volgt een verslag van enkele relevante presentaties voor de klinische praktijk.
Karotype Trisomie

Evolutie van de prenatale screening naar aneuploïdie in het eerste trimester: van leeftijd tot NIPT

Twee à vier procent van alle pasgeborenen heeft een min of meer ernstige aangeboren misvorming. De huidige prenatale diagnostiek probeert…

Respiratoire virologie – Wie zoekt, die vindt

Acute luchtweginfectie is het meest wijdverspreide type van acute infectie bij kinderen en volwassenen, en een significante oorzaak van ziekte bij immuungecompromitteerde patiënten. In 2002 waren respiratoire infecties verantwoordelijk voor 18% van de mortaliteit wereldwijd bij kinderen onder vijf jaar; diarree (15%) en malaria (11%) vormden de twee daaropvolgende belangrijkste oorzaken. Respiratoire infecties lokken niet enkel een toename van mortaliteit uit, maar veroorzaken eveneens een verhoogde morbiditeit in deze leeftijdsklasse.

Een snelle DNA-analyse voor de opsporing van foetale chromosoomafwijkingen

De triple en eerste trimester-screeningtesten, het uitgebreide echografische onderzoek en de leeftijd van de zwangere vrouw bepalen in sterke mate of er een verhoogd risico is op een numerieke chromosoomafwijking bij het ongeboren kind. Voor een snelle diagnose van de meest frequente foetale chromosoomafwijkingen werd recent een DNA-testmethode ontwikkeld, gebaseerd op de polymerase kettingreactie (PCR, Polymerase Chain Reaction).

Vitrificatie: Innovatieve invriestechniek met perspectieven

Succesvol invries-dooiprogramma in het Centrum voor Reproductieve Geneeskunde Brugge. Vandaag wordt zonder enige twijfel aanvaard dat het invriezen van reproductieve cellen en embryo’s een noodzakelijke procedure is bij elke vooruitstrevende techniek in het domein van de reproductieve geneeskunde.

Nieuwe laboratorium­benaderingen voor de preventie van cardiovasculaire morbiditeit en mortaliteit

Op 20 oktober 2007 vond in Brugge het Symposium van de Belgian Lipid Club (BLC) plaats, georganiseerd door dr. M. Langlois van het Laboratorium Klinische Scheikunde van AZ Sint­Jan AV en Prof. V. Blaton. Naast enkele toonaangevende opinieleiders (Prof. P. Lansberg en Prof. J. Kastelein van het departement Vasculaire Geneeskunde van de Universiteit Amsterdam, Prof. G. De Backer van de Universiteit Gent en Prof. L. Van Gaal van de Universiteit Antwerpen) gaven zij er een presentatie over nieuwe benaderingenvoor de preventie van cardiovasculaire morbiditeit en mortaliteit.

Innovatie in het lab toxicologie: TDM van immunosuppressiva met LC-MSMS

Therapeutische drug monitoring (TDM) van immunosuppressiva is essentieel om de farmacologische respons en het uiteindelijke resultaat van (orgaan)transplantaties te verbeteren. Bloedconcentraties moeten accuraat gemeten worden om een efficiënte en veilige therapie te garanderen, gezien de lage therapeutische index van de gebruikte geneesmiddelen (toxische/therapeutische dosis). Bovendien is er een risico op ernstige nevenwerkingen bij overdosering en transplantaatrejectie bij onderdosering.

Weefselbank AZ Sint-Jan AV bij FDA geregistreerd voor afname van hematopoiëtische stamcellen uit beenmerg en bloed

Onlangs behaalde de Bloedtransfusiedienst van het Laboratorium Hematologie van AZ Sint-Jan AV de ISO 9001- erkenning. Daarmee is ze de eerste Vlaamse bloedinstelling die een dergelijke erkenning geniet. Bovendien kreeg de Weefselbank een FDA-registratie voor de afname van hematopoiëtische stamcellen. Daarmee bewijst AZ Sint-Jan AV dat zij niet afwacht tot de overheid de zorgsector strengere kwaliteitsnormen oplegt maar haar patiënten en artsen nu al de beste kwaliteit biedt, vinden dr. Johan Billiet, dr. Arnold Criel en industrie-apotheker Dimitri Dehenau.

Publicaties

Prevention of nosocomial COVID-19: Another challenge of the pandemic.

Infect Control Hosp Epidemiol. 2020 Apr 23 : 1–2. Published online 2020 Apr 23. doi: 10.1017/ice.2020.166

“Hepatitis E Virus Genotype 3 subtype dependent clinical outcomes in Belgium 2010-2018“.

Suppl. in Journal of Hepatology 73:S857 August 2020, doi:10.1016/S0168-8278(20)32157-7

“Successful Outcome of Disseminated Fusarium musae Fungemia with Skin Localization Treated with Liposomal Amphotericin B and Voriconazole in a Patient with Acute Myeloid Leukemia”.

Mycopathologia. 2020 Oct 29. doi: 10.1007/s11046-020-00499-w.

“Capturing Respiratory Syncytial Virus season in Belgium using influenza Severe Acute Respiratory Infection surveillance network (season 2018-2019)”.

Euro Surveill. 2020;25(39): pii=1900627. https://doi.org/10.2807/1560-7917. ES.2020.25.39.1900627

“Comparison of four commercial SARS-Cov-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings”.

Infection.2020 Sep 10:1-4. doi: 10.1007/s15010-020-01523-3.

“Incidence, risk factors, timing and outcome of influenza versus Covid-19 associated putative invasive aspergillosis.”

Infect Control Hosp Epidemiol. 2020 Sep 9:1-7. doi: 10.1017/ice.2020.460.

“In Reply to ‘Is SARS-CoV-2 Serology Relevant for Hemodialysis Patients With COVID-19?”

Am J Kidney Dis. 2020 Jun 27:S0272-6386(20)30783-6. doi:10.1053/j.ajkd.2020.06.005

“IgG Antibody Response to SARS-CoV-2 Infection and Viral RNA Persistence in Patients on Maintenance Hemodialysis “.

American Journal of Kidney Diseases. 2020 Jun 5:S0272-6386(20)30733-2. doi: 10.1053/j.ajkd.2020.05.009.

“Epidemiology of Pneumocystis jirovecii Pneumonia and (Non-)use of Prophylaxis”.

Front. Cell. Infect. Microbiol., 15 May 2020. https://doi.org/10.3389/fcimb.2020.00224

“Prevention of nosociomial Covid-19: another challenge of the pandemic”.

Infect Control Hosp Epidemiol. 2020 Apr 23:1-2. doi: 10.1017/ice.2020.166.

“Hepatitis E virus-associated hemophagocytic lymphohistiocytosis”.

Acta Clinica Belgica 2020 Feb 24:1-4. doi: 10.1080/17843286.2020.1733179.

“Evolution, geographic spreading, and demographic distribution of Enterovirus D68”.

BioRxiv, January 2020. doi: https://doi.org/10.1101/2020.01.10.901553

“What is the risk of missing legionellosis relying on urinary antigen testing solely? A retrospective Belgian multicenter study”.

Eur J Clin Microbiol Infect Dis. 2020 Apr;39(4):729-734. doi: 10.1007/s10096-019- 03785-8. Epub 2019 Dec 14.PMID: 31838606

“Prevalence and macrolide resistance of Mycoplasma genitalium after initiation of HIV preexposure prophylaxis”.

Sex Transm Infect. 2020 Jan 2. pii: sextrans-2019-054335. doi: 10.1136/sextrans-2019-054335.

Evaluation of Next Generation Sequencing based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

International Journal of Laboratory Hematology 2019;41(2):242-249.

Targeted next generation DNA sequencing for the detection of clonal haematopoiesis in idiopathic cytopaenia of undetermined significance (ICUS).

Belgian Journal of Hematology 2019;10:231-40

Spuriously high MCV in a patient with diabetic ketoacidosis.

Belgian Journal of Hematology 2019;10:250-4

Malignant progressionof Donor-engrafted Clonal hematopoiesis in sibling recipients after stem cell transplantation.

Blood Advances, Volume 4, Issue 22

The CCA Special Issue on Cardiovascular Markers.

Clin Chim Acta. 2020 [Editorial] doi: 10.1016/j.cca.2020.10.036

Update on current practice in laboratory medicine in respect of natriuretic peptide testing for heart failure diagnosis and management in Europe.

The CARdiac MArker Guideline Uptake in Europe (CARMAGUE) study. Clin Chim Acta 2020;511:59-66.

How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe?

The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) study. Chim Acta. 2020;508:267-272.

Non-HDL Cholesterol or apoB: Which to Prefer as a Target for the Prevention of Atherosclerotic Cardiovascular Disease?

Curr Cardiol Rep. 2020;22:67.

Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.

Atherosclerosis 2020;294:46-61.

Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.

Clin Chem Lab Med. 2020;58:496-517.

Evolving concepts on the management of dyslipidaemia.

Acta Clin Belg – Int J Clin Lab Med 2020;75:80-90.

Investigations on the clinical utility of apolipoprotein B measurement: A research priority.

Eur J Prev Cardiol. 2020;27:1252–1254 [Editorial].

Muscle strength is a major determinant of the blood pressure response to isometric stress testing: the Asklepios population study.

J Hypertens 2020;38:224-234.

“Serial detection of circulating Mucorales DNA in invasive mucormycosis: a retrospective multicentre evaluation”.

Journal of Fungi 2019. Accepted December 2019

“A Decade of Enterovirus Genetic Diversity in Belgium”.

J Clin Virol 2019. Oct 25;121:104205. doi: 10.1016/j.jcv.2019.104205.

“Human bocavirus infection in Belgian children with respiratory tract disease”.

Arch Virol. 2019 Sep 13. doi: 10.1007/s00705-019-04396-6.

“Toxoplasma gondii-Induced Brachial Plexus Neuropathy after Allogeneic Hematopoietic Stem Cell Transplantation”.

Transpl Infect Dis. 2019 Aug 8:e13157. doi: 10.1111/tid.13157.

“Lateral flow assays for diagnosing invasive pulmonary aspergillosis in adult hematology patients: a comparative multicenter study”.

Medical Mycology. 2019 Jul 9. doi: 10.1093/mmy/myz079

“Evaluation of the VIDAS hepatitis E IgM test in a nonendemic region”.

Diagn Microbiol Infect Dis. 2019. May 6. pii: S0732-8893(18)30567-4. doi: 10.1016/j.diagmicrobio.2019.04.012.

“Epidemiology and clinical impact of viral, atypical, and fungal respiratory pathogens in symptomatic immunocompromised patients: a two-center study using a multi-parameter customized respiratory Taqman® array card.”

Eur J Clin Microbiol Infect Dis. 2019 May 20. doi: 10.1007/s10096-019-03579-y

“The development and establishment of the 1st WHO BKV International Standard for nucleic acid based techniques”.

Biologicals. 2019 May 17 doi: 10.1016/j.biologicals.2019.04.004.

“A case of a surgical-site infection with Staphylococcus condimenti”.

“Oseltamivir for prophylaxis of influenza in vaccinated hemodialysis patients”

Infect Control Hosp Epidemiol. 2019 Apr;40(4):497-498. doi: 10.1017/ice.2019.11.

“Diagnosing invasive pulmonary aspergillosis in hematology patients: Retrospective multicenter evaluation of a novel lateral flow device”.

J Clin Microbiol. 2019 Mar 28;57(4). pii: e01913-18. doi: 10.1128/JCM.01913-18.

Evaluation of Next Generation Sequencing based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

International Journal of Laboratory Hematology 2019;41(2):242-249.

Targeted next generation DNA sequencing for the detection of clonal haematopoiesis in idiopathic cytopaenia of undetermined significance (ICUS).

Belgian Journal of Hematology 2019;10:231-40

Spuriously high MCV in a patient with diabetic ketoacidosis.

Belgian Journal of Hematology 2019;10:250-4

Diagnostic testing in myeloid malignancies by next-generation sequencing: recommendations from the Commission Personalised Medicine.

BELG J HAEMATOL 2019;10(6):241-9

Targeted next generation DNA sequencing for the detection of clonal haematopoiesis in idiopathic cytopaenia of undetermined significance (ICUS).

BELG J HAEMATOL 2019;10(6):231-40

Kappa Free Light Chains Is a Valid Tool in the Diagnostics of MS: A Large Multicenter Study.

Multiple Sclerosis Journal, 2019, DOI: 10.1177/1352458519845844

Bone marrow metastases from a 1p/19q co-deleted oligodendroglioma- a case report.

Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.

Atherosclerosis 2020 doi: 10.1016/j.atherosclerosis.2019.12.005.

Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.

Clin Chem Lab Med. 2019 doi: 10.1515/cclm-2019-1253.

Evolving concepts on the management of dyslipidaemia.

Acta Clin Belg – Int J Clin Lab Med 2019 https://doi.org/10.1080/17843286.2019.1702823

Muscle strength is a major determinant of the blood pressure response to isometric stress testing: the Asklepios population study.

J Hypertens 2020;38:224-234.

Investigations on the clinical utility of apolipoprotein B measurement: A research priority.

Eur J Prev Cardiol. 2019 doi: 10.1177/2047487319869578

Evaluation of next-generation sequencing-based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

8.

Int J Lab Hematol. 2018 Dec 8.

“Disseminated Mycobacterium genavense Infection in an immuno-competent Adult: a case report.”

Clin Microbiol Infect. 2018 Dec;24(12):1355-1356. doi: 10.1016/j.cmi.2018.07.013. Epub 2018 Jul 21.

“Diagnostic Utility of the Lymphoid Screening Tube for Ogata Score Calculation in Patients with Peripheral Cytopenia”.

Hematology. 2018 Dec;24(1):166-172.

An unexpected Campylobacter fetus infection.

Infection. 2018 Oct;46(5):729-730. doi: 10.1007/s15010-018-1159-8.

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion.

Acta Haematol 2018;140:97–104

Evaluation of the CellaVision DM96 advanced RBC application for screening and follow-up of malaria infection.

Diagn Microbiol Infect Dis. 2018 Apr;90(4):253-256. doi: 10.1016/j.diagmicrobio.2017.12.002.

Evaluation of four hemoglobin separation analyzers for hemoglobinopathy diagnosis.

J Clin Lab Anal. 2018;32:e22224.

Leukocyte telomere length and diet in the apparently healthy, middle-aged Asklepios population.

Sci Rep. 2018;8:6540.

Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM.

Clin Chem. 2018;64:1006-1033.

The Role of Nutraceuticals in Statin Intolerant Patients.

J Am Coll Cardiol. 2018;72:96-118.

Which Lipids Should Be Analyzed for Diagnostic Workup and Follow-up of Patients with Hyperlipidemias?

Curr Cardiol Rep. 2018;20:88.

Overview of the current status of familial hypercholesterolaemia care in over 60 countries – The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).

Atherosclerosis. 2018;277:234-255.

A Belgian consensus strategy to identify familial hypercholesterolaemia in the coronary care unit and its subsequent cascade screening and treatment: BEL-FaHST (The BELgium Familial Hypercholesterolaemia STrategy).

Atherosclerosis. 2018;277:369-376.

“Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: A nested case-control approach”

BMC Infectious Diseases - INFD-D-18-00197R3; 2018

“Viral co-infections involving influenza A: changes observed during the 2009 pandemic season.”

Infect Dis Diag Treat. 2018 IDDT-116. doi: 10.29011/IDDT-116. 100016

“Prevalence and distribution of HCV genotypes in Belgium from 2008 to 2015.”

PLoS ONE 2018;13(12): e0207584

Isolation of Communicable Diseases.

GUIDE TO INFECTION CONTROL IN THE HOSPITAL CHAPTER 7 - Ed Gonzalo Bearman 2018

International consensus on ANA patterns (ICAP): inbedding in het Nederlandse taalgebied.

Laboratoriumgeneeskunde 2018;3:17-26

Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used.

Leukemia 2018; 32(8):1815-1818

Antigen excess detection by automated assays for free light chains.

Clin Chem Lab Med 2018; 56(9) e235-e238. doi: 10.1515/cclm-2017-0977

Analytical performance of the single well titer function of NOVA View: good enough to omit ANA IIF titer analysis?

Clin Chem Lab Med 2018; 56(11):258-261.

Evaluation of Four Hemoglobin Separation Analyzers for Hemoglobinopathy Diagnosis.

Journal of Clinical Lab Analysis 2018;32(1)

Revised 2017 international consensus on ANCA testing in small vessel vasculitis: support from an external quality assessment.

Ann Rheum Dis 2018 Sept 5; pii: annrheumdis-2018-214078. doi: 10.1136/annrheumdis-2018-214078. [Epub ahead of print]

Evaluation of the CellaVision DM96 Advanced RBC Application for screening and follow-up of malaria infection.

Diagnostic Microbiology and Infectious Disease 2018;90(4):253-256

Diagnostic utility of the lymphoid screening tube supplemented with CD34 for Ogata score calculation in patients with peripheral cytopenia.

Hematology 2018;24(1):166-172.

“A disseminated Mycoplasma hominis infection in a patient with an underlying defect in humoral immunity”.

Infection. 44(3):379-81.

First EAS – EFLM consensus guideline on non-fasting lipid testing and reporting.

IFCC e-newsletter May-June 2016;20-21.

Lipidentesten op niet-nuchtere bloedafnames.

Eur Heart J 2016 en Clin Chem 2016 namens de Europese EAS/EFLM expertgroep

“Lipiden en lipoproteïnen” In: Wegwijs in Laboratoriumdiagnose.

Uitgeverij Acco 2016 p. 273-92. ISBN 978-94-6292-305-8.

Why are clinical practice guidelines not followed?

Clin Chem Lab Med. 2016;54:1133-9.

Haptoglobin phenotype and Parkinson disease risk.

Parkinsonism Relat Disord. 2016;22:108-9.

“Analytical and clinical comparison of Elecsys Syphilis (Roche®) – Architect Syphilis TP and Reformulated Architect Syphilis TP (Abbott®) assay”

Diagnostic Microbiology and Infectious Diseases 2016; DMID-16-734R2

Evaluation of the Red Blood Cell Advanced Software Application on the DM96.

International Journal of Laboratory Hematology 2016, 38(4):366-74.

Fasting is not routinely required for determination of a lipid profile-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.

Eur Heart J. 2016;37:1944-58

Fasting Is Not Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints.

Clin Chem. 2016;62:930-46.

How Well Do Laboratories Adhere to Recommended Clinical Guidelines for the Management of Myocardial Infarction: The CARdiac MArker Guidelines Uptake in Europe Study (CARMAGUE).

.

Clin Chem. 2016;62:1264-71.

Could accreditation bodies facilitate the implementation of medical guidelines in laboratories?

Clin Chem Lab Med. 2016 [Epub ahead of print]

“Therapeutic drug monitoring of meropenem in necrotizing enterocolitis: a challenge”.

Case Reports in Infectious Diseases 2016; 2016: 6207487.

“Heads or tails: genotyping of Hepatitis C Virus concerning the 2k/1b circulating recombinant form”.

International Journal of Molecular Sciences (Int J Mol Sci) 2016, 17(9),1384; doi:10.3390/ijms17091384

“Mycoplasma hominis: more than just an innocent bystander”.

Journal of Antimicrobial Agents (J Antimicro). 2(2):114. doi:10.4172/2472-1212.1000114

Dose finding study of rivaroxaban in hemodialysis patients.

American Journal of Kidney Diseases 2015;66(1):91-8.

Evaluation of Schistocyte Analysis by a Novel Automated Digital Cell Morphology Application.

International Journal of Laboratory Hematology 2015;37(5):588-96

Analysis of Phenotype and Outcome in Essential Thrombocythemia with CALR and JAK2 mutations.

Haematologica 2015;100(7):893-7.

Acquired thrombin and FV inhibitors upon aortic bioprosthetic valve replacement.

Haemophilia. 2014 Jul;20(4):e354-6. doi: 10.1111/hae.12469.

Biclonal biphenotypic B-cell lymphocytosis: a CLL in disguise?

Belgian Journal of Hematology 2014;5(4):143-7

HDL-gerichte therapieën: behandeling van een risicofactor of make-up van een risicomerker?

ISBN 978-90-81054-26-3 Transmed Medical Communications 2013 pp. 29-46.

Serum amyloid A is independently related to apolipoprotein A-I but not to HDL-cholesterol in patients with angina pectoris Clin Biochem.

2013 [Epub ahead of print].

Genetic aspects of scurvy and the European famine of 1845-1848

Nutrients 2013; 5:3582-8.

Comparison of two immunoassays for measurement of faecal calprotectin in detection of Inflammatory Bowel Disease: (pre)-analytical and diagnostic performance characteristics.

Clin Chem Lab Med 2013 (in press).

Guideline from the European Atherosclerosis Society: clinical view on laboratory checklist and issues

Biochimica clinica 2013; 375(Suppl.):S36

Critical review of laboratory investigations in clinical practice guidelines: proposals for the description of investigation.

Clin Chem Lab Med. 2013; 51:1217-26.

Pseudonephritis is Associated With High Urinary Osmolality and High Specific Gravity in Adolescent Soccer Players.

Pediatr Exerc Sci. 2013; 25:360-9

Accuracy of three automated 25-hydroxyvitamin D assays in haemodialysis patients

Clin Chim Acta 2013; 415:255-60

Microparticle number or procoagulant activity are not upregulated in healthy elderly persons.

Thromb Res. 2012;129(1): 98-100

Is it time to apply genographics in medical diagnosis?

Acta Clin Belgica 2012;67:387-8.

Human plasma protein polymorphisms and the persistence of cultural diversity.

Proc Natl Acad Sci U S A. 2012;109(43):E2914.

How I treat dyslipidemia according to the cardiovascular risk profile?

Rev Med Liège 2012; 67:167-173.

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels

PLoS ONE 2012;7:e32327

Postanalytical opportunities of lipid and lipoprotein testing:laboratory approaches for predicting and managing risk of cardiovascular disease

Clin Chem Lab Med (invited article) 2012; 50:1169–1181.

The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients

J Eur Acad Dermatol Venereol 2012; 26:566-71.

Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis.

Thromb Res. 2012; 129(4): 514-9

The effect of air pollution on hemostasis

Hamostaseologie 2012; 32(1): 5-13

Microparticle number or procoagulant activity are not upregulated in healthy elderly persons

Thromb Res. 2012;129(1): 98-100

Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy

60(4): 324-31

Hemostatic changes in young and old mice upon subchronic exposure to air pollution in an urban roadside tunnel

108(4): 756-68

Changed gene expression in brains of mice exposed to traffic in a highway tunnel.

24(10): 676-686

Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of FVIII.

10(7): 1371-8.

Effect of ageing on the murine venous circulation

137(4): 537-46

Air pollution-associated procoagulant changes: role of circulating microvesicles.

J Thromb Haemost 2012;1 0(1): 96-106

Presentaties

Infectiepreventie op de werkvloer in Covid tijden. Financiële impact van de Covid-crisis op de werking van het ziekenhuis.

15/06/2020
Brugge

Update Covid 19 Webinar AZ St Jan Brugge (deel infectiepreventie).

28/04/2020
Brugge

Webinar HABO vzw: “COVID-19 Labodiagnostiek: een overzicht van de meest courante testmethoden”.

03/12/2020
Brugge

“Hepatitis E Virus Genotype 3 subtype dependent clinical outcomes in Belgium 2010-2018“.

18-21/04/2020
Parijs

Casuistiek flowcytometrie.

26/11/2020
NVC/SKML congres (virtueel)

Comparative Evaluation of Automated Mechanical Tissue Dissociation for Flow Cytometric Analysis.

20/11/2020
RBSLM congres (virtueel)

Challenging diagnostic assessment of germline RUNX1 variants in myeloid malignancies: a case report of a patient presenting with a novel RUNX1 variant.

01//07/2020
EHA (virtueel)

Immunophenotypic and molecular features of cuplike morphology in AML.

14/02/2020
La Hulpe

Donor cell-derived acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: molecular confirmation by next-generation sequencing.

14/02/2020
La Hulpe

Comparative evaluation of automated mechanical tissue dissociation for flow cytometric analysis.

01/01/2020

CHALLENGING DIAGNOSTIC ASSESSMENT OF GERMLINE RUNX1 VARIANTS IN MYELOID MALIGNANCIES: A CASE REPORT OF A PATIENT PRESENTING WITH A NOVEL GERMLINE RUNX1 VARIANT.

21/06/2020
Brugge

Immunophenotypic and molecular phenotyping of cup-like morphology in AML.

14/02/2020
Brussel

Donor cell-derived acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation: molecular confirmation by next-generation sequencing.

14/02/2020
Brussel

Early relapse detection after allogeneic stem cell transplantation by chimerism analysis based on Next Generation Sequencing of insertion/deletion polymorphisms.

29/04/2020
Glasgow UK

CASE REPORT: SPURIOUSLY HIGH VITAMIN A AND E LEVELS DUE TO HYPERLIPIDEMIA.

26/10/2020
Virtual RBSLM Annual Meeting (Royal Belgian Society of Laboratory Medicine)

Lipid testing in 2020.

04/06/2020
Webinar CCA (Clin Chim Acta)

Sessie “Viral respiratory infections: diagnostic options & epidemiology”

30/11/2019
Dolce La Hulpe

“Application of multi-parameter screening for the diagnosis of infectious diseases”

26/09/2019
Evergem

AB-BeleidsSymposium: “Nieuwe anti-infectieuze therapie anno 2019” “Update over virale en fungale infecties: diagnostische testen”

18/06/2019
Brugge

“Non-influenza viruses associated with Severe Acute Respiratory Infections during influenza seasons 2015/2016 to 2017/2018, Belgium”

27-29/11/2019
Stockholm, Sweden

“Increased prevalence of macrolide-resistant Mycoplasma genitalium after initiation of HIV pre-exposure prophylaxis”

02-06/10/2019
Washington, USA

“RSV infection in hospitalized adults with severe acute respiratory infection during four influenza seasons in Belgium: prevalence, subtype distribution, risk factors and outcome”

13-16/04/2019
Amsterdam

“COMPARISON OF THE REALSTAR® QUANTITATIVE PCR KIT AND A LABORATORY DEVELOPED SEMI-QUANTITATIVE PCR FOR THE DETECTION OF PNEUMOCYSTIS JIROVECII IN RESPIRATORY SAMPLES”

15/11/2019
Brussel

“Epidemiology of Pneumocysits jirovecii pneumonia and (non-)use of prophylaxis in three tertiary care hospitals”.

11-14/10/2019
Nice, France

“Evaluation of the Altona RealStar® Pneumocystis jirovecii PCR kit 1.0 for quantitative detection of Pneumocystis jirovecii in various sample types”.

09-11/10/2019
Noordwijk aan Zee, Nederland

“Enterovirus surveillance of 2018 reveals an upsurge of EV-D68 in Belgium”.

11-14/09/2019
Copenhagen, Denmark

“Epidemiology of human respiratory syncytial virus circulating in Belgium between 2011 and 2019” -abstract ID 241.

11-14/09/2019
Copenhagen, Denmark

“RUBELLA SEROLOGY IN BELGIUM: WHAT’S IN A NUMBER?”

11-14/09/2019
Copenhagen, Denmark

“Viral Compartmentalization and Rapid Evolution of Drug-resistant Herpes Simplex Virus (HSV-1) Infection in a Hematopoietic Stem Cell Transplant (HSCT) Patient.

12-15/05/2019
Baltimore, Maryland, USA

“Epidemiology and Clinical Impact of Respiratory Pathogens in Symptomatic Immunocompromised Patients: a Two-center Study using a Multi-parameter Customized Respiratory Taqman Array Card”.

13-16/04/2019
Amsterdam

“Evaluation of the FilmArray Meningitis/Encephalitis panel in routine setting: a Belgian multicenter study”.

13-16/04/2019
Amsterdam

“Diagnostic characteristics of the recently commercialized OLM AspLFD lateral flow device in hematology patients: a multicenter study”.

13-16/04/2019
Amsterdam

“Improving the diagnostic performance of the newly commercialized IMMY Aspergillus galactomannan lateral flow assay using digital readout”.

13-16/04/2019
Amsterdam

“Bordetella pertussis seroprevalence in Belgian adults aged 40-59 years, 2017”.

09-12/04/2019
Brussel

TTP: diagnose, behandeling en FU.

10/10/2019
Antwerpen

Digitale microscopie.

08/10/2019
Brugge

Digitale microscopie.

26/03/2019
Kortrijk

Anemie.

09/02/2019
Brugge

Vernieuwingen in de stamcelbank.

06/11/2019
Brugge

Plaats van mutatieanalyse bij donorselectie: 2 voorbeelden.

17/10/2019
Drongen

Celvrij DNA: nieuwe diagnostische mogelijkheden.

09/02/2019
Brugge

Clonal hematopoiesis.

08/02/2019
Brugge

Droplet Digital PCR Phasing (DROP-PHASE): A Novel Method for Straightforward Detection of BCR-ABL1 Compound Mutations in Tyrosine Kinase Inhibitors Resistant Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL).

07-10/12/2019
Orlando

Results from the LIME survey ANA methodology. Sciensano symposium. The importance of harmonization in ANA testing. Latest progress of harmonization initiatives.

22/11/2019
Antwerpen

14th Dresden symposium on autoantibodies. 5th International Consensus on ANA Pattern (ICAP) Workshop 4th International Autoantibody Standardization (IAS) Workshop.

10-13/09/2019
Dresden

Update on Dyslipidaemia Guidelines and the rationale of Cardiovascular Disease Biomarker.

23/05/2019
Barcelona

“Hepatitis E virus-associated haemophagocytic lymphohistiocytosis“.

20/12/2018
Brussel

Chloordioxide en koper-zilver ionisatie in de strijd tegen Legionella, een ervaringsverslag.

“Application of multiparameter screening & Taqman Array Card for the diagnosis of infectious diseases”

04/12/2018
UZ Gent

Casuistiek

22/11/2018
Zwolle, Nederland

“Evaluation of Simplexa™ C. difficile Direct assay for rapid diagnosis of Clostridium difficile infection compared to a multi-parameter customized respiratory TaqMan® array card”.

16/11/2018
Brussel

“Circulating strains of Human respiratory syncytial virus in Belgium during seven consecutive respiratory seasons (2011-2018)”.

31-04/10-11/2018
Asheville, USA

“Overzicht diagnostiek CZS infecties”.

23/10/2018
Gent

Een handvol Neurotrope Virussen.

19/10/2018
Brugge

LOK: Rol van NGS in de diagnostiek en prognose van MDS.

25/09/2018
Brugge

“Incidence and Clinical Relevance of Human Bocavirus (HBoV) Infections in Pediatric Patients”.

23-26/09/2018
Athens, Greece

“Evaluation of Alere™ i for rapid detection of RSV and influenza A&B compared to a multi-parameter customized respiratory TaqMan® array card”.

23-26/09/2018
Athens, Greece

Rol van NGS in de diagnostiek en prognose van MDS.

11/09/2018
Oostkamp

“Update in diagnostiek van SOA’s met nadruk op syphilis & M.genitalium”.

06/09/2018
Moorsel

GENE PANEL ANALYSIS BY NEXT GENERATION SEQUENCING FOR THE DETECTION OF CLONAL HAEMATOPOIESIS IN IDIOPATHIC CYTOPENIA OF UNDETERMINED SIGNIFICANCE (ICUS) AND MYELODYSPLASTIC SYNDROME (MDS).

14/06/2018
Stokholm, Zweden

Case report: regular plasmapheresis in hyperchylomicronemia.

13/06/2018
Valencia, Spanje

Comparison between Spectra optia® CMNC and MNC protocol for autologous peripheral blood stem cell collections.

13/06/2018
Valencia, Spanje

Ogata-score berekening adhv de Lymphoid Screening Tube (LST) in de diagnose van MDS.

05/06/2018
Woerden, Nederland

Progress in antigen excess detection.

31/05/2018
Antwerpen

“Decentralized Universal Neonatal Cytomagalovirus screening in Ghent and Bruges, Belgium”

14-15/05/2018
Brussel

Diagnostic utility of the Lymphoid Screening Tube for Ogata score calculation in MDS investigation.

12/05/2018
Brussel

Trainee breakfast panel.

11/05/2018
Brussel

Antibioticagebruik in de thuiszorg vanuit economisch aspect.

Vergelijking HPLC toestellen voor screening hemoglobinopathieën.

02/05/2018
Aalter

Principes van hemostase in vitro.

19/04/2018
Brussel

“Microbiological tools for CNS infections” (“Microbiologie voor de neuroloog”).

Uitbraak van een multi-resistente Acinetobacter baumannii op Intensieve Zorgen. Antimicrobial resistance – AMR The difference we must make together.

09/03/2018
Brussel

Problematiek van multi-resistente bacteriën.

06/03/2018
Brugge

Validation of first trimester non-invasive fetal RhD genotyping for targeted antenatalo anti-D prophylaxis.

02/02/2018
La Hulpe

Evaluation of the CellaVision DM96 Advanced RBC Application for screening and follow-up of malaria infection.

02/02/2018
La Hulpe

Diagnostic utility of the Lymphoid Screening Tube for Ogata score calculation in MDS investigation.

02/02/2018
La Hulpe

Bloed en beenmerg bij MDS.

27/01/2018
Sijsele

Total complement activity (CH50): evaluation of thermostability and comparison of 2 liposome based assays OPtilite The Binding Site versus Autokit Wako.

01/01/2018
Lissabon

Analytical performance of the single well titer function of NOVA View: good enough to omit ANA IIF titer analysis?

01/01/2018
Lissabon

“Diagnostic tools in meningo-encephalitis”

2-3/12/2016
UZB Jette

Urgenties in de laboratoriumhematologie.

01/12/2016
Brugge

“Versant HCV Genotype 2.0 assay (LiPA) misclassifies the circulating HCV recombinant RF1_2k/1b in genotype 2 patients”

11-15/11/2016
Boston

“Viral Respiratory Tract infections in immunocompromised patients”

22/10/2016
Brugge

Evaluation of Four Hemoglobin A1c Instruments.

14/10/2016
Seraing

“Prospective study in Belgian children hospitalized with RSV related lower respiratory tract infections: characterization of viral and clinical symptoms kinetics confirms a correlation between RSV viral load and disease severity.”

28/09-01/10/2016
Patagonia, Argentina

“Dyslipidemia- New clinical concepts and diagnostic tools”

23/09/2016
Warschau

Evaluation of Four Hemoglobin A1c Instruments.

21-24/09/2016
Warschau

Evaluation of Four Hemoglobin A1c Instruments.

21/09/2016
Warschau, Polen

“Focus diagnostics Simplexa™ Flu A/B & RSV versus multi-parameter customized respiratory Taqman® Array Card in immunocompromised patients”

14-17/09/2016
Lisbon, Portugal

“Characterization of clinical and viral kinetics in children hospitalized with respiratory syncytial virus related lower respiratory tract infections”

3-7/09/2016
London

“Non-fasting lipid profiles: implications for lipoprotein measurement and reporting”

07/06/2016
EFLM e-seminar

“Etiology of community-acquired respiratory infection & New Diagnostic Methods in Viral RTI”

24/05/2016
AZ Sint-Jan Brugge-Oostende AV

INVLOED VAN NOAC’s OP ROUTINE EN SPECIALE STOLLINGSTESTEN.

12/05/2016
Brussel

Monoclonale B-cellymfocytose.

23/04/2016
Brugge

Urgenties in de laboratoriumhematologie.

19/04/2016
Brussel

“Heads or tails: genotyping of Hepatitis C Virus concerning the 2k/1b recombinant”

8-12/04/2016
Amsterdam

“Versant HCV Genotype 2.0 assay (LiPA) misclassifies the circulating HCV recombinant RF1_2k/1b in genotype 2 patients”

18-20/02/2016
Brussel

The conundrum of hematocrit measurements on hematopoietic progenitor cell apheresis products: differences between cell counters.

29/01/2016
La Hulpe

Evaluation of the Red Blood Cell Advanced Software Application on the CellaVision DM96.

29/01/2016
La Hulpe

STANDARDIZATION OF MRD DETECTION IN CML BY USE OF A PEER GROUP CONVERSION FACTOR

01/01/2013
Stockholm

“Haptoglobin genotype and risk markers of cardiovascular disease”

27/09/2013
Denemarken

LOK Cardiologie Richtlijnen en valkuilen bij het management van dyslipidemie

09/09/2013
Brugge

Euromedlab IFCC-EFLM Congress

22/05/2013
Milaan

Comparison of two extraction devices for determination of faecal calprotectin on ImmunoCAP250

19/05/2013
Milaan

Serum amyloid A is independently related to apolipoprotein A-I but not to HDL-cholesterol in patients with angina pectoris

19/05/2013
Milaan

Accuracy of three automated 25-hydroxyvitamin D immunoassays compared to ID-XLC-MSMS in haemodialysis patients

19/05/2013
Milaan

Accuracy of three automated immunoassays compared to ID-XLC-MSMS for the measurement of 25-hydroxyvitamin D in haemodialysis patients

20/10/2012
Gent

jaarlijks symposium CRG

13/06/2012
Brugge

16éme Journée de Biologie Clinique

12/05/2012
Brussel

EliA™ CTD screen: enzyme fluoroimmunoassay for ANA detection

Symposium KBVKC, EAS Guidelines for dyslipidemia management

03/05/2012
Groot-Bijgaarden
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