Discipline: Hematologie
Stamceltransplantatieprogramma behaalt JACIE-accreditering
Het Europese accrediteringsorgaan JACIE heeft aan het stamceltransplantatieprogramma van het AZ Sint-Jan Brugge-Oostende AV een gerenommeerd, internationaal kwaliteitslabel toegekend voor…
Medical mystery: vermagering, anemie en verhoogd LDH
Een 72-jarige patiënte consulteert omwille van vermoeidheid, duidelijke vermagering en anorexie, gepaard met horror carnis en zwarte stoelgang. In 1999 onderging ze een tumorectomie met okselklierevidement voor een borstcarcinoom in de linkerborst, stadium pT2pN0M0, gevolgd door chemotherapie en bestraling.
Behandeling op maat voor acute myeloïde leukemie
Acute myeloïde leukemie – AML – is de meest voorkomende vorm van acute leukemie bij volwassenen (incidentie: 2 tot 3 per 100.000 personen). De incidentie stijgt met de leeftijd, waardoor AML hoofdzakelijk een aandoening is van de oudere patiënt. De behandeling wordt bepaald door de leeftijdscategorie, de comorbiditeit en het cytogenetisch-moleculair onderzoek.
Succesvol MDS-patiëntenforum legt basis voor officiële zelfhulpgroep
Van 18 tot 21 mei 2011 vond in Edinburgh het 11de International Symposium on Myelodysplastic Syndromes (MDS) plaats, een initiatief van de MDS Foundation. Aan het symposium was eveneens een “Nurses Program” verbonden. Op de eerste dag kwam daar voornamelijk theorie aan bod over de ziekte zelf, medicatie, prognoses, studies, enz. Tijdens de tweede dag stond een internationaal patiëntenforum op het programma Vanessa Pröckl, oncologisch verpleegkundige op de dienst Hematologie van het AZ Sint-Jan Brugge-Oostende AV, vergezelde er een MDS-patiënt die enkele jaren geleden een stamceltransplantatie had ondergaan op haar hematologische verpleegeenheid.
Allogene stamceltransplantatie
Een allogene hematopoïetische stamceltransplantatie (SCT) is een behandeling waarbij de patiënt bloedvormende stamcellen van een donor toegediend krijgt. Deze behandeling heeft sinds de eerste toepassingen eind de jaren 70 heel wat ontwikkelingen doorgemaakt.
Zevalin-therapie
Non-Hodgkin lymfoom, waarvan de incidentie wereldwijd toeneemt, is een frequente diagnose, met een incidentie van ongeveer 10 gevallen per 100.000 mannen en 8 gevallen per 100.000 vrouwen. Onder de noemer non-Hodgkin lymfoom worden een groot aantal aandoeningen gegroepeerd met een sterk uiteenlopend klinisch gedrag. De globale groep wordt dan ook vaak opgedeeld in laaggradige lymfomen, die traag maar gestadig evolueren en hooggradige lymfomen, die veeleer agressief evolueren.
Publicaties
Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma.
Eur Respir J. 2022 Feb 10;59(2):2101724. doi: 10.1183/13993003.01724-2021. Print 2022 Feb.PMID: 34446469 Free PMC article. Clinical Trial.
Life-threatening autoimmune hemolytic anemia following mRNA COVID-19 vaccination: don’t be too prudent with the red gold.
Clin Chem Lab Med. 2022 Mar 11;60(6):e125-e128. doi: 10.1515/cclm-2022-0118. Print 2022 May 25.PMID: 35278047 Free article. No abstract available.
A unique phenotype of longitudinal extensive transverse myelitis in autoimmune lymphoproliferative syndrome.
J Neuroimmunol. 2022 Jun 15;367:577866. doi: 10.1016/j.jneuroim.2022.577866. Epub 2022 Apr 12.PMID: 35453041
Performance of the JF5-Based Galactomannoprotein EIA Compared to the Lateral Flow Device and the Galactomannan EIA in Serum and Bronchoalveolar Lavage Fluid.
J Clin Microbiol. 2022 Oct 10:e0094822. doi: 10.1128/jcm.00948-22. Online ahead of print.PMID: 36214562
Sequential administration of low dose 5-azacytidine (AZA) and donor lymphocyte infusion (DLI) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in relapse after allogeneic stem cell transplantation (SCT): a prospective study from the Belgian Hematology Society (BHS).
Bone Marrow Transplant. 2022 Jan;57(1):116-118. doi: 10.1038/s41409-021-01464-x.
Correction to: Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML.
Leukemia. 2021 Dec;35(12):3637. doi: 10.1038/s41375-021-01473-1.
Clofarabine added to intensive treatment in adult patients with newly diagnosed ALL: the HOVON-100 trial.
Blood Adv. 2022 Feb 22;6(4):1115-1125. doi: 10.1182/bloodadvances.2021005624.
Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
Hematology. 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645.
Parvovirus B19-triggered hemophagocytic lymphohistiocytosis in a patient with Crohn’s disease.
Acta Gastroenterol Belg. 2022 Jul-Sep;85(3):522-524. doi: 10.51821/85.3.9108.
Empiric versus pre-emptive antifungal strategy in high-risk neutropenic patients on fluconazole prophylaxis: a randomized trial of the European organization for Research and Treatment of cancer (EORTC 65091).
Clin Infect Dis. 2022 Jul 30:ciac623. doi: 10.1093/cid/ciac623.
Postremission cytopenia management in patients with acute myeloid leukemia treated with venetoclax and azacitidine in VIALE-A.
Am J Hematol. 2022 Nov;97(11):E416-E419. doi: 10.1002/ajh.26692.
Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase.
J Antimicrob Chemother. 2022 Sep 5:dkac297. doi: 10.1093/jac/dkac297.
Obinutuzumab plus lenalidomide in advanced, previously untreated follicular lymphoma in need of systemic therapy: a LYSA study.
Blood 2022 Apr 14;139(15):2338-2346. doi: 10.1182/blood.2021013526. -PMID: 34936697 DOI: 10.1182/blood.2021013526
Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML.
Leukemia. 2021 Jul;35(7):2119-2124. doi: 10.1038/s41375-021-01125-4. Epub 2021 Jan 22. PMID: 33483617 Free PMC article. Clinical Trial. No abstract available.
Efficacy of ruxolitinib in B-lymphoblastic leukaemia with the PCM1-JAK2 fusion gene.
Br J Haematol. 2021 Feb;192(4):e112-e115. doi: 10.1111/bjh.17340. Epub 2021 Jan 27. PMID: 33502001 No abstract available.
Primary immune thrombocytopenia in adults: Belgian recommendations for diagnosis and treatment anno 2021 made by the Belgian Hematology Society.
Acta Clin Belg. 2021 Feb 26:1-14. doi: 10.1080/17843286.2021.1876310. Online ahead of print. PMID: 33635747
Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission.
N Engl J Med. 2020 Dec 24;383(26):2526-2537. doi: 10.1056/NEJMoa2004444. PMID: 33369355 Clinical Trial.
Effectiveness and Safety of Romiplostim Among Patients with Newly Diagnosed, Persistent and Chronic Immune Thrombocytopenia in European Clinical Practice.
Adv Ther. 2021 May;38(5):2673-2688. doi: 10.1007/s12325-021-01727-5. Epub 2021 Apr 18. PMID: 33866516 Free PMC article.
Clinical outcomes in patients with Philadelphia chromosome-positive leukemia treated with ponatinib in routine clinical practice-data from a Belgian registry.
Ann Hematol. 2021 Jul;100(7):1723-1732. doi: 10.1007/s00277-021-04507-x. Epub 2021 May 4. PMID: 33942128 Free PMC article.
A phase 2a randomized clinical trial of intravenous vedolizumab for the treatment of steroid-refractory intestinal acute graft-versus-host disease.
Bone Marrow Transplant. 2021 Oct;56(10):2477-2488. doi: 10.1038/s41409-021-01356-0. Epub 2021 Jun 9. PMID: 34108672 Free PMC article. Clinical Trial.
Management of adverse events in patients with acute myeloid leukemia in remission receiving oral azacitidine: experience from the phase 3 randomized QUAZAR AML-001 trial.
J Hematol Oncol. 2021 Aug 28;14(1):133. doi: 10.1186/s13045-021-01142-x. PMID: 34454540 Free PMC article. Clinical Trial.
Oral azacitidine preserves favorable level of fatigue and health-related quality of life for patients with acute myeloid leukemia in remission: results from the phase 3, placebo-controlled QUAZAR AML-001 trial.
Haematologica. 2021 Sep 23. doi: 10.3324/haematol.2021.279174. Online ahead of print. PMID: 34551506 Free article.
Sequential administration of low dose 5-azacytidine (AZA) and donor lymphocyte infusion (DLI) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in relapse after allogeneic stem cell transplantation (SCT): a prospective study from the Belgian Hematology Society (BHS).
Bone Marrow Transplant. 2021 Oct 5. doi: 10.1038/s41409-021-01464-x. Online ahead of print. PMID: 34611291 No abstract available.
High total metabolic tumor volume at baseline predicts survival independent of response to therapy.
Blood. 2020 Apr 16;135(16):1396-1405. doi: 10.1182/blood.2019003526.PMID: 31978225 Free PMC article. Clinical Trial.
Lenalidomide maintenance for diffuse large B-cell lymphoma patients responding to R-CHOP: quality of life, dosing, and safety results from the randomised controlled REMARC study.
Br J Haematol. 2020 Apr;189(1):84-96. doi: 10.1111/bjh.16300. Epub 2019 Nov 8.PMID: 31702836 Free PMC article.
TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment.
Haematologica. 2020 May;105(5):1306-1316. doi: 10.3324/haematol.2019.222612. Epub 2019 Aug 1.PMID: 31371409 Free PMC article
Guidelines of the Belgian Hematology Society on the use of stem cell transplantation in lymphoproliferative diseases.
Belgian journal of hematology volume 10 issue 2 march 2019 p 69-79.
Lenalidomide maintenance for diffuse large B-cell lymphoma patients responding to R-CHOP: quality of life, dosing, and safety results from the randomised controlled REMARC study.
Br J Haematol. 2019 Nov 8. doi: 10.1111/bjh.16300. PMID: 31702836
TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment.
Haematologica. 2019 Aug 1. pii: haematol.2019.222612. doi: 10.3324/haematol.2019.222612. PMID: 31371409
Obinutuzumab combined with lenalidomide for relapsed or refractory follicular B-cell lymphoma (GALEN): a multicentre, single-arm, phase 2 study.
Lancet Haematol. 2019 Aug;6(8):e429-e437. doi: 10.1016/S2352-3026(19)30089-4. Epub 2019 Jul 8. PMID: 31296423
Bing-Neel Syndrome: two unexpected cases and review of the literature.
Journal of the Neurological Sciences 2015;356(1-2):19-26.
Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model.
Blood 2011; 117: 4615-22
Acquired thrombin and FV inhibitors upon aortic bioprosthetic valve replacement.
Haemophilia. 2014;20(4):e354-6. doi: 10.1111/hae.12469.
Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy.
J Am Coll Cardiol 2012; 60(4): 324-31
Hemostatic changes in young and old mice upon subchronic exposure to air pollution in an urban roadside tunnel.
Thromb Haemost 2012; 108(4): 756-68.
Changed gene expression in brains of mice exposed to traffic in a highway tunnel.
Inhalation Toxicology 2012; 24(10): 676-686.
Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of FVIII.
J Thromb Haemost 2012; 10(7): 1371-8.
Effect of ageing on the murine venous circulation.
Histochem Cell Biol 2012; 137(4): 537-46
Air pollution-associated procoagulant changes: role of circulating microvesicles.
J Thromb Haemost 2012;1 0(1): 96-106
The effect of air pollution on hemostasis.
Hamostaseologie 2012; 32(1): 5-13
Microparticle number or procoagulant activity are not upregulated in healthy elderly persons.
Thromb Res. 2012;129(1): 98-100
Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy.
J Am Coll Cardiol 2012; 60(4): 324-31
Hemostatic changes in young and old mice upon subchronic exposure to air pollution in an urban roadside tunnel.
Thromb Haemost 2012; 108(4): 756-68.
Changed gene expression in brains of mice exposed to traffic in a highway tunnel.
Inhalation Toxicology 2012; 24(10): 676-686.
Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of FVIII.
J Thromb Haemost 2012; 10(7): 1371-8.
Effect of ageing on the murine venous circulation.
Histochem Cell Biol 2012; 137(4): 537-46
Air pollution-associated procoagulant changes: role of circulating microvesicles.
Thromb Haemost 2012;1 0(1): 96-106
Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis.
Thromb Res. 2012; 129(4): 514-9
The effect of air pollution on hemostasis.
Hamostaseologie 2012; 32(1): 5-13
The influence of air pollution on health: mechanistic implications.
Verh K Acad Geneeskd Belg 2011; 73(5-6): 339-51
Effecten van fijn stof op bloedplaatjesactivatie en atherosclerose in een populatie van diabetespatiënten.
Vlaams Tijdschrift voor Diabetologie 2011, 2: 19-21
The impact of air pollution on health, economy, environment and agricultural sources.
Rijeka: Croatia InTech 2011; 69-92.
Progression of the pro-thrombotic state in ageing BMAL1 deficient mice.
Arterioscler Thromb Vasc Biol 2011; 31: 2552-9
Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombosis but has no effect on atherogenesis.
J Mol Med 2011; 89: 1051-8
Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model.
Blood 2011; 117: 4615-22
Traffic Air Pollution and Oxidized LDL.
PLoS One 2011; 6: e16200
Air pollution and cardiovascular disease.The impact of air pollution on health, economy, environment and agricultural sources.
Khallaf (ed). Rijeka: Croatia, InTech 2011; 69-92.
The influence of air pollution on health: mechanistic implications.
Verh K Acad Geneeskd Belg 2011; 73(5-6): 339-51
Effecten van fijn stof op bloedplaatjesactivatie en atherosclerose in een populatie van diabetespatiënten.
Vlaams Tijdschrift voor Diabetologie 2011, 2: 19-21
Progression of the pro-thrombotic state in ageing BMAL1 deficient mice.
Arterioscler Thromb Vasc Biol 2011; 31: 2552-9
Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombosis but has no effect on atherogenesis.
J Mol Med 2011; 89: 1051-8
Traffic Air Pollution and Oxidized LDL.
PLoS One 2011; 6: e16200
Short-term exposure to particulate matter induces arterial but not venous thrombosis in healthy mice.
J Thromb Haemost 2010; 8: 2651-2661
Air pollution related prothrombotic changes in persons with diabetes.
Environ Health Perspect 2010; 118: 191-196
Short-term exposure to particulate matter induces arterial but not venous thrombosis in healthy mice.
J Thromb Haemost 2010; 8: 2651-2661
Air pollution related prothrombotic changes in persons with diabetes.
Environ Health Perspect 2010; 118: 191-196
Het endotheel: tussen hemostase en inflammatie.
De Agenda Cardiologie 2008; 22: 4-6
Het endotheel: tussen hemostase en inflammatie.
De Agenda Cardiologie 2008; 22: 4-6