Multidisciplinaire aanpak van orthopedische en posttraumatische infecties

Wereldwijd is er een groei in orthopedische activiteit, met o.a. een stijging van het aantal geplaatste heup- en knieprothesen. Daarnaast is er een problematiek van toenemende bacteriële resistentie tegen antibiotica. Bijgevolg loopt zowel het aantal chronische als moeilijk te behandelen postoperatieve infecties de laatste jaren op. Vandaar dat het AZ Sint-Jan Brugge-Oostende AV in de benadering van infecties voor een grondige multidisciplinaire aanpak koos.

CT-beeld van granulomateuze letsels in lever en milt

Medical mystery: man met ademhalingsgebonden pijn, gewichtsverlies en nachtzweten

Een 35-jarige man komt op consultatie met ademhalingsgebonden pijn in het rechterhypochondrium. De pijn is er sinds een tweetal weken en straalt uit naar de rechterschouder. Bij navraag vermeldt de patiënt een gewichtsverlies van 17 kg op vier maanden tijd, hoewel hij zijn eetlust bewaarde, en ook nachtzweten zonder duidelijke koorts.

Medical mystery: man met aneurysma van de aorta en terugkerende rugpijn

Een 66-jarige man met in de voorgeschiedenis een monoclonale gammopathie van onbepaalde betekenis (IgG-kappa) wordt verwezen wegens rugpijn. In het verleden werd hij reeds geëvalueerd omwille van pijn in de kuiten en aan de achillespezen. Onderzoek wees toen op de aanwezigheid van HLA-B27 met een positieve familiale anamnese van psoriasis artritis, maar klinisch en echografisch werden geen bijzonderheden vastgesteld en de botscan was negatief. Hij maakt regelmatig avontuurlijke reizen naar verschillende continenten en doet intensief aan wielersport. Als medicatie neemt hij enkel acetylsalicylzuur en solifenacine.

Medical mystery: verhoogde TSH-waarde

Een 28-jarige vrouw komt op de raadpleging Endocrinologie omwille van een verhoogde TSH-waarde (thyroïdstimulerend hormoon) bij een routinelaboratoriumonderzoek verricht door de huisarts. De patiënte vertoont geen symptomen van hypothyroïdie en de halspalpatie is normaal.

Betere levenskwaliteit ondanks Onverklaarde Lichamelijke Klachten

In de Kliniek voor Onverklaarde Lichamelijke Klachten (KOLK) van AZ Sint-Jan AV kunnen volwassen patiënten terecht met reeds langer bestaande lichamelijke klachten waarvoor geen medisch-organische verklaring wordt gevonden. Kenmerkend voor de polikliniek is de multidisciplinaire benadering van de patiënt. Een team specialisten zet zich in om de symptomen van de patiënten te verlichten en de levenskwaliteit te verbeteren.

New insights in pharmacokinetics and pharmacodynamics of antibiotics: implications for the treatment of peritonitis

49th ERA-EDTA Congress, Parijs
24/05/2012

Serologische benadering van membraneuze nefropathie

LOK Nefrologie Gent
14/03/2017

Complement en nierziekten

LOK Nefrologie Gent
23/06/2015

Afwijkingen van de alternatieve complement pathway

LOK Nefrologie Aalst
25/11/2014

CKD-MBD: an update

Renal Rounds Amgen, Brugge
15/10/2015

Perorale anticoagulatie bij dialysepatiënten

Renal Rounds Amgen/Fresenius, Hasselt
16/12/2014

Dialysis in the Pocket

Baxter Predialysis Award, Braine-l’Alleud
22/10/2013

An update in peritoneal dialysis

Nephro Update Europe, Vienna
06/10/2017

Oral anticoagulation in hemodialysis patients: challenges and opportunities

34th Biennal Congres of the Nordic Society of Nephrology, Malmö
20/09/2017

Oral anticoagulation in dialysis: alternatives to warfarin.

Congres of the Iranian Society of Nephrology, Shiraz
19/05/2017

The use of vancomycin in CKD, hemodialysis and peritoneal dialysis

Srinagar
03/09/2015

Oral anticoagulation in dialysis patients

Srinagar
03/09/2015

Oral anticoagulation in dialysis patients: challenges and opportunities

Cardiology Divisional Grand Rounds, Mazankowski Alberta Heart Institute, Edmonton
27/05/2015

Old and new antibiotics in dialysis

3rd International Renal Meeting in Sardinia, Cagliari
02/052015

“Should we use vitamin K antagonists in hemodialysis patients?”

Tröndheim
02/09/2016

“Oral anticoagulation in hemodialysis: new insights”.

Argentina, Buenos Aires
07/05/2016

Regional variation of thyroid cancer in Belgium

European Thyroid Association
08/09/2014

“Hemodialysis catheters: does design matter ?”

Santiago de Chili
5-7/05/2014

“Vitamin K and vascular calcifications”.

Santiago de Chili
5-7/05/2014

“The evidence for intensive dialysis: frequent and prolonged dialysis, hemodiafiltration”.

Santiago de Chili
5-7/05/2014

Regional Variation of Thyroid cancer in Belgium

Belgian
26/04/2014

L’incidence du cancer de la thyroid, est-elle en augmentation?

UCL congres d’endocrinologie
29/03/2014

Hoe hypofysepathologie onderkennen?

Brugge
27/03/2014

“Vitamin K antagonists in dialysis: navigating between Scylla and Charybdis”.

Brugge
21/03/2014

Vancomycin: the tale of the vanquisher and the Pyrrhic victory

Maastricht
12 oktober 2013:

“Hemodialysis, do we need individualized treatment prescriptions ?”

Sardinia, Cagliari
30/04/2013

Toon meer

Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group.

Ann Hematol. 2016 Jan;95(2):191-9.
01/01/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial.

Lancet. 2016 Feb 20;387(10020):760-9.
20/02/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia.

Future Oncol. 2016 Feb;12(3):293-302.
01/02/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

Gemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 Trial.

J Clin Oncol. 2016 Mar 20;34(9):972-9
20/03/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med. 2016 Mar 2;8(328):328ra30.
02/03/2016

» http://www.ncbi.nlm.nih.gov/pubmed/

A large observational study of patients with primary immune thrombocytopenia receiving romiplostim in European clinical practice.

Eur J Haematol. 2017 Feb;98(2):112-120.
01/02/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

5.Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT.

Biol Blood Marrow Transplant. 2017 Jan;23(1):44-52.
01/01/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Low-dose clofarabine in combination with a standard remission induction in patients aged 18-60 years with previously untreated intermediate and bad-risk acute myeloid leukemia or high-risk myelodysplastic syndrome: combined phase I/II results of the EORTC/GIMEMA AML-14A trial.

Haematologica. 2017 Feb;102(2):e47-e51.
01/02/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q).

J Hematol Oncol. 2017 Jun 26;10(1):131
26/06/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Impact of unresolved neutropenia in patients with neutropenia and invasive aspergillosis: a post hoc analysis of the SECURE trial.

J Antimicrob Chemother.
29/11/2017

» http://www.ncbi.nlm.nih.gov/pubmed/

Vancomycin: the tale of the vanquisher and the Pyrrhic victory.

Perit Dial Int 2014; 34: 154-61
01/01/2014

The incidence of primary versus secondary focal and segmental glomerulosclerosis: a clinicopathological study.

Mayo Clin Proc 2017
01/01/2017

. Interstitial immunostaining and renal outcomes in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

Am J Nephrol 2017
01/01/2017

Familial anti-glomerular basement membrane disease in zero HLA mismatch siblings.

Clin Nephrol 2017
01/01/2017

Should statins be banned from dialysis?

J Am Soc Nephrol 2017;28:1675-1676.
01/01/2017

A Proposal for Standardized Grading of Chronic Changes in Native Kidney Biopsy Specimens.

Kidney Int 2017;91:787-789.
01/01/2017

Fibromuscular dysplasia: results of a multicenter study in Flanders.

Vasa 2017;46:211-218.
01/01/2017

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference.

Kidney Int 2017;91:539-551.
01/01/2017

A proposal for a serology-driven approach to membranous nephropathy.

J Am Soc Nephrol 2017;28:421-430.
01/01/2017

Glomerular disease caused by dysregulation of the complement alternative pathway: an etiologic approach.

J Am Soc Nephrol 2015; 26: 2917-2929
01/01/2015

In reply to “Hemodialysis catheters: which design is more cost-effective? And “Use of an uncensored primary outcome in a catheter design trial”

Am J Kidney Dis 2015; 66: 171
01/01/2015

Opponent’s comments

Nephrol Dial Transplant 2015; 30: 898-899
01/01/2015

Biomarkers in glomerular diseases: putting the cart before the wheel?

Nephrol Dial Transplant 2015; 30: 885-890
01/01/2015

C4d as a diagnostic tool in the diagnosis of proliferative glomerulonephritis

J Am Soc Nephrol
01/01/2015

High homocysteine induces betaine depletion.

Biosci Rep 2015; 35: pii:e00222
01/01/2015

Vitamin K antagonists for stroke prevention in hemodialysis patients with atrial fibrillation: a meta-analysis.

Am Heart J 2016; 184: 37-46.
01/01/2016

What are we missing in the clinical trials of focal segmental glomerulosclerosis?

Nephrol Dial Transplant 2017;32(suppl_1):i14-i21.
01/01/2017

Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: Results of a proteomic analysis.

Nephrol Dial Transplant 2017;32(suppl_1):i139-i145
01/01/2017

Temporal IgG subtype changes in recurrent idiopathic membranous nephropathy.

Am J Transplant 2016; 16: 2964-72.
01/01/2016

The atrial fibrillation conundrum in dialysis patients.

Am Heart J 2016; 174: 111-119.
01/01/2016

The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials.

Clin Kidney J 2016; 9: 273-279.
01/01/2016

Diagnosis of complement alternative pathway disorders.

Kidney Int 2016; 89: 278-288.
01/01/2016

Mayo Clinic/ Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of Glomerulonephritis.

J Am Soc Nephrol 2016; 27: 1278-87.
01/01/2016

C3 glomerulonephritis and autoimmune disease: more than a fortuitous association?

J Nephrol 2016; 29: 203-9.
01/01/2016

Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass.

Muscle Nerve. 2015 Aug;52(2):278-88. doi: 10.1002/mus.24542.
01/08/2015

Body composition, bone turnover, and bone mass in trans men during testosterone treatment: 1-year follow-up data from a prospective case-controlled study (ENIGI).

Eur J Endocrinol. 2015 Feb;172(2):163-71. doi: 10.1530/EJE-14-0586.
01/02/2015

Preservation of volumetric bone density and geometry in trans women during cross-sex hormonal therapy: a prospective observational study.

Osteoporos Int. 2015 Jan;26(1):35-47. doi: 10.1007/s00198-014-2805-3.
26/01/2015

A multicomponent approach to identify predictors of hospital outcomes in older in-patients: a multicentre, observational study.

PLoS One. 2014 Dec 26;9(12):e115413. doi: 10.1371/journal.pone.0115413. eCollection 2014.
26/12/2014

Progressive dysphagia caused by Erdheim-Chester disease.

QJM. 2014 Dec;107(12):1015-7. doi: 10.1093/qjmed/hcs061. Epub 2012 Mar 30. No abstract available. PMID:22466415
01/12/2014

Relation of adrenal-derived steroids with bone maturation, mineral density and geometry in healthy prepubertal and early pubertal boys.

Bone. 2014 Dec;69:39-46. doi: 10.1016/j.bone.2014.09.002.
01/12/2014

A bone scan, no mistake !

J Clin Endocrinol Metab 2014; 99: 4447-8
01/01/2014

Influenza vaccination and humoral alloimmunity in solid organ transplant recipients.

Transpl Int. 2014 Sep;27(9):903-8. doi: 10.1111/tri.12345. Epub 2014 Jun 17. PMID: 24797932
01/09/2014

The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial.

Transpl Int. 2014 Sep;27(9):895-902. doi: 10.1111/tri.12287.
01/09/2014

Sex steroids in relation to sexual and skeletal maturation in obese male adolescents.

J Clin Endocrinol Metab. 2014 Aug;99(8):2977-85. doi: 10.1210/jc.2014-1452
01/08/2014

Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: a cross-sectional study in healthy male adolescents.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1272-82. doi: 10.1210/jc.2013-3887.
01/07/2014

Functional changes during hospital stay in older patients admitted to an acute care ward: a multicenter observational study.

PLoS One. 2014 May 12;9(5):e96398. doi: 10.1371/journal.pone.0096398.
12/05/2014

Association between insulin resistance, lean mass and muscle torque/force in proximal versus distal body parts in healthy young men.

J Musculoskelet Neuronal Interact. 2014 Mar;14(1):41-9.
01/03/2014

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

PLoS Genet. 2014 Feb 27;10(2):e1004123. doi: 10.1371/journal.pgen.1004123
27/02/2014

Genetic variations in the androgen receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men.

PLoS One. 2014 Jan 23;9(1):e86235. doi: 10.1371/journal.pone.0086235.
23/01/2014

Hemodialysis catheter design and catheter performance: a randomized controlled trial.

Am J Kidney Dis 2014, Apr 5.
01/01/2014

Vitamin K2 Supplementation in Hemodialysis Patients: a Randomized Dosefinding Study.

Nephrol Dial Transplant 2014; 29: 1385-90.
01/01/2014

In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions

Diabetologia. ;56(9):1964-70. doi: 10.1007/s00125-013-2951-8
01/09/2013

Regional Variation in Thyroid Cancer Incidence in Belgium Is Associated With Variation in Thyroid Imaging and Thyroid Disease Management

J Clin Endocrinol Metab;98(10):4063-4071
21/08/2013

Cystatin C versus creatinine for kidney function-based risk.

N Engl J Med 2013; 369: 2458-9.
01/01/2013

Methylation defect in imprinted genes detected in patients with an Albright’s hereditary osteodystrophy like phenotype and platelet Gs hypofunction.

PLoS One. 2012;7(6):e38579. doi: 10.1371/journal.pone.0038579
05/06/2012

Regionale verschillen in de incidentie van schildklierkanker in België: rol van de diagnostische en therapeutische aanpak van schildklierpathologie.

Health Services Research (HSR). Brussel: Federaal Kenniscentrum voor de Gezondheidszorg (KCE). 2012 KCE Report 177 As. D/2012/10.273/27
2012

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