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Opsporing van Kingella kingae-DNA bij osteo-articulaire infecties bij kinderen
Bij kinderen komen osteo-articulaire infecties (OAI) zoals osteomyelitis, septische artritis en spondylodiscitis relatief weinig voor. Gezien een OAI tot ernstige…
Innovaties verruimen diagnostische mogelijkheden binnen de microbiologie
Dankzij de introductie van nieuwe moleculaire amplificatietechnieken en de MALDI-TOF massaspectrometer heeft de medische microbiologie de laatste jaren een enorme…
Medical mystery: man met ademhalingsgebonden pijn, gewichtsverlies en nachtzweten
Een 35-jarige man komt op consultatie met ademhalingsgebonden pijn in het rechterhypochondrium. De pijn is er sinds een tweetal weken en straalt uit naar de rechterschouder. Bij navraag vermeldt de patiënt een gewichtsverlies van 17 kg op vier maanden tijd, hoewel hij zijn eetlust bewaarde, en ook nachtzweten zonder duidelijke koorts.
Respiratoire virologie – Wie zoekt, die vindt
Acute luchtweginfectie is het meest wijdverspreide type van acute infectie bij kinderen en volwassenen, en een significante oorzaak van ziekte bij immuungecompromitteerde patiënten. In 2002 waren respiratoire infecties verantwoordelijk voor 18% van de mortaliteit wereldwijd bij kinderen onder vijf jaar; diarree (15%) en malaria (11%) vormden de twee daaropvolgende belangrijkste oorzaken. Respiratoire infecties lokken niet enkel een toename van mortaliteit uit, maar veroorzaken eveneens een verhoogde morbiditeit in deze leeftijdsklasse.
“Importance of anti-SARS-CoV-2 assay antigenic composition as revealed by the results of the Belgian external quality assessment (EQA) scheme”
Diagn Microbiol Infect Dis. 2021 Oct 11;102(2):115561. doi:10.1016/j.diagmicrobio.2021.115561. Online ahead of print.
“Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021”
Euro Surveill. 2021 Nov;26(45). doi: 10.2807/1560-7917.ES.2021.26.45.2100998.
“Evaluation of the SARS-CoV-2 positivity ratio and upper respiratory tract viral load among asymptomatic individuals screened before hospitalization or surgery in Flanders, Belgium”
PlosOne. 2021 Nov 11;16(11):e0259908. doi: 10.1371/journal.pone.0259908
“Multicenter evaluation of the FilmArray Meningitis/Encephalitis assay in routine setting”
Journal of Medical Microbiology 2021. Accepted Sept 11. JMM-D-21-00276R1
“Acute SARS-CoV-2 Alpha variant infection leading to placental insufficiency and fetal distress”
J Med Virol. 2021 Oct 7. doi: 10.1002/jmv.27379.
“Predictors and dynamics of the humoral and cellular immune response to SARS-CoV-2 vaccination in hemodialysis patients: a multicenter observational study”
J Am Soc Nephrol. 2021 Sep 29: ASN.2021070908. doi:10.1681/ASN.2021070908.
“High prevalence of co-infecting enteropathogens in suspected rotavirus vaccine breakthrough cases”
J Clin Microbiol. 2021 Sep 29:JCM0123621.doi:10.1128/JCM.01236-21.
“Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, 2015-2019, Belgium”
Euro Surveill. 2021 Sep;26(38). doi: 10.2807/1560-7917.ES.2021.26.38.2001104.
“Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis”
Emerg Infect Dis. 2021 Sep 14;27(11). doi: 10.3201/eid2711.211174.
“COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges.”
Intensive Care Med. 2021 Sep 1:1-2. doi: 10.1007/s00134-021-06510-2.
“Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents”
J Infect Dis. 2021 Sep 13:jiab458.doi: 10.1093/infdis/jiab458. Online ahead of print.
“Mapping of serological testing and SARS-CoV-2 seroprevalence studies performed in 20 European countries, March-June 2020”
Journal of Global Health 2021 (J Glob Health 2021;11:05014) *representative of Belgium: M.Reynders
“Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients– a multinational observational study by the European Confederation of Medical Mycology”
Clin Microbiol Infect. 2021 Aug 25:S1198-743X(21)00474-2.doi:10.1016/j.cmi.2021.08.014. Online ahead of print.
“Longevity and correlation with disease severity of the humoral and cellular response to SARS-CoV-2 infection in haemodialysis patients”
Clinical Kidney Journal. 2021 Aug 13;14(11):2446-2448. doi:10.1093/ckj/sfab147. eCollection 2021 Nov.
“Comparison of 4 commercial enzyme immunoassays for serology testing of human parvovirus B19 infection”
Diagn Microbiol Infect Dis. 2021 Jul 16;101(3):115489. doi:10.1016/j.diagmicrobio.2021.115489.
“Diagnosis and treatment of COVID-19 associated pulmonary aspergillosis in critically ill patients: results from a European confederation of medical mycology registry”
Intensive Care Med. 2021 Jul 16 : 1–3. doi: 10.1007/s00134-021-06471-6
“Posaconazole for prevention of invasive pulmonary Aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial”
Intensive Care Med. 2021 Jun;47(6):674-686. doi: 10.1007/s00134-021-06431-0. Epub 2021 May 29.
“Pitfalls of rubella serology while on the brink of elimination: evaluation of national data, Belgium, 2017”
Euro Surveill. 2021 May ;26(20). doi: 10.2807/1560-7917.ES.2021.26.20.2000074.
“Humoral and cellular immunogenicity of the BNT162b2 mRNA Covid-19 Vaccine in nursing home residents”
Clin Infect Dis. 2021 Apr 7:ciab300. doi: 10.1093/cid/ciab300.
“Monitoring of human coronaviruses in Belgian ambulatories and hospitals in 2015-20: a surveillance study”
Lancet Microbe. 2021 Mar;2(3):e105-e114. doi: 10.1016/S2666-5247(20)30221-4. Epub 2021 Jan 27.
Longevity and correlation with disease severity of the humoral and cellular response to SARS-CoV-2 infection in hemodialysis patients.
Clin Kidney J 2021; 14: 2446-2448.
Predictors and dynamics of the humoral and cellular immune response to SARS-CoV-2 mRNA vaccines in hemodialysis patients: a multicenter observational study.
J Am Soc Nephrol 2021.
Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents.
J Infect Dis 2021.
Humoral and cellular immunogenicity and safety of the BNT162b2 mRNA Covid-19 Vaccine in nursing home residents.
Clin Inf Dis 2021.
Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents.
J Infect Dis. 2021 Sep 13:jiab458.
Humoral and cellular immunogenicity of the BNT162b2 mRNA Covid-19 Vaccine in nursing home residents.
Clinicial Infectious Diseases 2021. Apr 7:ciab300. doi: 10.1093/cid/ciab300.
Incidence, risk factors, timing and outcome of influenza versus Covid-19 associated putative invasive aspergillosis.
Infection Control and Hospital Epidemiology, 2021, Sep;42(9):1149-1150
Multicenter evaluation of the FilmArray Meningitis/Encephalitis assay in a routine setting.
Med Microbiol. 2021 Oct;70(10). doi: 10.1099/jmm.0.001438.PMID: 34665115
Dynamics of the cellular and humoral immune response after BNT162b2 mRNA Covid-19 vaccination in Covid-19 naive nursing home residents.
J Infect Dis 2021. Online ahead of print.
Predictors and Dynamics of the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccines in Hemodialysis Patients: A Multicenter Observational Study.
J Am Soc Nephrol 2021; 32 :3208-20.
Longevity and correlation with disease severity of the humoral and cellular response to SARS-CoV-2 infection in haemodialysis patients.
Clin Kidney J 2021;14(11):2446-2448.
Humoral and cellular immunogenicity of the BNT162b2 mRNA Covid-19 Vaccine in nursing home residents.
Clin Infect Dis 2021; Online ahead of print.
Incidence, risk factors, timing and outcome of influenza versus Covid-19 associated putative invasive aspergillosis.
Infection Control and Hospital Epidemiology, 2020
Epidemiology of Pneumocystis jirovecii Pneumonia and (Non-)use of Prophylaxis.
Front Cell Infect Microbiol. 2020 May 15;10:224. doi: 10.3389/fcimb.2020.00224.
Mycoplasma genitalium acquisition and macrolide resistance after initiation of HIV pre-exposure prophylaxis in men who have sex with men.
Sex Transm Infect. 2020 Sep;96(6):396-398.
In Reply to ‘Is SARS-CoV-2 Serology Relevant for Hemodialysis Patients With COVID-19?’
Am J Kidney Dis 2020.
IgG Antibody Response to SARS-CoV-2 Infection and Viral RNA Persistence in Patients on Maintenance Hemodialysis.
Am J Kidney Dis 2020
Mycoplasma genitalium acquisition and macrolide resistance after initiation of HIV pre-exposure prophylaxis in men who have sex with men.
Sex Transm Infect. 2020; 96:396-398
Incidence, risk factors, timing and outcome of influenza versus Covid-19 associated putative invasive aspergillosis.
Infect Control Hosp Epidemiol. 2020 Sep 9:1-7. doi: 10.1017/ice.2020.460.
Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings.
Infection. 2020 doi: 10.1007/s15010-020-01523-3.
Successful Outcome of Disseminated Fusarium musae Fungemia with Skin Localization Treated with Liposomal Amphotericin B and Voriconazole in a Patient with Acute Myeloid Leukemia.
Mycopathologia. 2020 doi: 10.1007/s11046-020-00499-w
Prevention of nosocomial COVID-19: Another challenge of the pandemic.
Infect Control Hosp Epidemiol. 2020 Apr 23 : 1–2. Published online 2020 Apr 23. doi: 10.1017/ice.2020.166
“Hepatitis E Virus Genotype 3 subtype dependent clinical outcomes in Belgium 2010-2018“.
Suppl. in Journal of Hepatology 73:S857 August 2020, doi:10.1016/S0168-8278(20)32157-7
“Successful Outcome of Disseminated Fusarium musae Fungemia with Skin Localization Treated with Liposomal Amphotericin B and Voriconazole in a Patient with Acute Myeloid Leukemia”.
Mycopathologia. 2020 Oct 29. doi: 10.1007/s11046-020-00499-w.
“Capturing Respiratory Syncytial Virus season in Belgium using influenza Severe Acute Respiratory Infection surveillance network (season 2018-2019)”.
Euro Surveill. 2020;25(39): pii=1900627. https://doi.org/10.2807/1560-7917. ES.2020.25.39.1900627
“Comparison of four commercial SARS-Cov-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings”.
Infection.2020 Sep 10:1-4. doi: 10.1007/s15010-020-01523-3.
“Incidence, risk factors, timing and outcome of influenza versus Covid-19 associated putative invasive aspergillosis.”
Infect Control Hosp Epidemiol. 2020 Sep 9:1-7. doi: 10.1017/ice.2020.460.
“In Reply to ‘Is SARS-CoV-2 Serology Relevant for Hemodialysis Patients With COVID-19?”
Am J Kidney Dis. 2020 Jun 27:S0272-6386(20)30783-6. doi:10.1053/j.ajkd.2020.06.005
“IgG Antibody Response to SARS-CoV-2 Infection and Viral RNA Persistence in Patients on Maintenance Hemodialysis “.
American Journal of Kidney Diseases. 2020 Jun 5:S0272-6386(20)30733-2. doi: 10.1053/j.ajkd.2020.05.009.
“Epidemiology of Pneumocystis jirovecii Pneumonia and (Non-)use of Prophylaxis”.
Front. Cell. Infect. Microbiol., 15 May 2020. https://doi.org/10.3389/fcimb.2020.00224
“Prevention of nosociomial Covid-19: another challenge of the pandemic”.
Infect Control Hosp Epidemiol. 2020 Apr 23:1-2. doi: 10.1017/ice.2020.166.
“Hepatitis E virus-associated hemophagocytic lymphohistiocytosis”.
Acta Clinica Belgica 2020 Feb 24:1-4. doi: 10.1080/17843286.2020.1733179.
“Evolution, geographic spreading, and demographic distribution of Enterovirus D68”.
BioRxiv, January 2020. doi: https://doi.org/10.1101/2020.01.10.901553
“What is the risk of missing legionellosis relying on urinary antigen testing solely? A retrospective Belgian multicenter study”.
Eur J Clin Microbiol Infect Dis. 2020 Apr;39(4):729-734. doi: 10.1007/s10096-019- 03785-8. Epub 2019 Dec 14.PMID: 31838606
“Prevalence and macrolide resistance of Mycoplasma genitalium after initiation of HIV preexposure prophylaxis”.
Sex Transm Infect. 2020 Jan 2. pii: sextrans-2019-054335. doi: 10.1136/sextrans-2019-054335.
A case of a surgical-site infection with Staphylococcus condimenti.
Infection. 2019 Oct;47(5):853-856. doi: 10.1007/s15010-019-01276-8. Epub 2019 Apr 5.
“Serial detection of circulating Mucorales DNA in invasive mucormycosis: a retrospective multicentre evaluation”.
Journal of Fungi 2019. Accepted December 2019
“A Decade of Enterovirus Genetic Diversity in Belgium”.
J Clin Virol 2019. Oct 25;121:104205. doi: 10.1016/j.jcv.2019.104205.
“Human bocavirus infection in Belgian children with respiratory tract disease”.
Arch Virol. 2019 Sep 13. doi: 10.1007/s00705-019-04396-6.
“Toxoplasma gondii-Induced Brachial Plexus Neuropathy after Allogeneic Hematopoietic Stem Cell Transplantation”.
Transpl Infect Dis. 2019 Aug 8:e13157. doi: 10.1111/tid.13157.
“Lateral flow assays for diagnosing invasive pulmonary aspergillosis in adult hematology patients: a comparative multicenter study”.
Medical Mycology. 2019 Jul 9. doi: 10.1093/mmy/myz079
“Evaluation of the VIDAS hepatitis E IgM test in a nonendemic region”.
Diagn Microbiol Infect Dis. 2019. May 6. pii: S0732-8893(18)30567-4. doi: 10.1016/j.diagmicrobio.2019.04.012.
“Epidemiology and clinical impact of viral, atypical, and fungal respiratory pathogens in symptomatic immunocompromised patients: a two-center study using a multi-parameter customized respiratory Taqman® array card.”
Eur J Clin Microbiol Infect Dis. 2019 May 20. doi: 10.1007/s10096-019-03579-y
“The development and establishment of the 1st WHO BKV International Standard for nucleic acid based techniques”.
Biologicals. 2019 May 17 doi: 10.1016/j.biologicals.2019.04.004.
“Oseltamivir for prophylaxis of influenza in vaccinated hemodialysis patients”
Infect Control Hosp Epidemiol. 2019 Apr;40(4):497-498. doi: 10.1017/ice.2019.11.
“Diagnosing invasive pulmonary aspergillosis in hematology patients: Retrospective multicenter evaluation of a novel lateral flow device”.
J Clin Microbiol. 2019 Mar 28;57(4). pii: e01913-18. doi: 10.1128/JCM.01913-18.
Oseltamivir for prophylaxis of influenza in vaccinated hemodialysis patients.
Infect Control Hosp Epidemiol. 2019 Apr;40(4):497-498. doi: 10.1017/ice.2019.11.
A case of a surgical-site infection with Staphylococcus condimenti.
Infection. 2019 Oct;47(5):853-856. doi: 10.1007/s15010-019-01276-8.
“Disseminated Mycobacterium genavense Infection in an immuno-competent Adult: a case report.”
Clin Microbiol Infect. 2018 Dec;24(12):1355-1356. doi: 10.1016/j.cmi.2018.07.013. Epub 2018 Jul 21.
“Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: A nested case-control approach”
BMC Infectious Diseases - INFD-D-18-00197R3; 2018
“Viral co-infections involving influenza A: changes observed during the 2009 pandemic season.”
Infect Dis Diag Treat. 2018 IDDT-116. doi: 10.29011/IDDT-116. 100016
“Prevalence and distribution of HCV genotypes in Belgium from 2008 to 2015.”
PLoS ONE 2018;13(12): e0207584
“A disseminated Mycoplasma hominis infection in a patient with an underlying defect in humoral immunity”.
Infection. 44(3):379-81.
Prolonged course of hepatic granulomatous disease due to Bartonella henselae infection.
Acta gastro-enterologica Belgica 2016;79:497-9.
“Analytical and clinical comparison of Elecsys Syphilis (Roche®) – Architect Syphilis TP and Reformulated Architect Syphilis TP (Abbott®) assay”
Diagnostic Microbiology and Infectious Diseases 2016; DMID-16-734R2
“Therapeutic drug monitoring of meropenem in necrotizing enterocolitis: a challenge”.
Case Reports in Infectious Diseases 2016; 2016: 6207487.
“Heads or tails: genotyping of Hepatitis C Virus concerning the 2k/1b circulating recombinant form”.
International Journal of Molecular Sciences (Int J Mol Sci) 2016, 17(9),1384; doi:10.3390/ijms17091384
“Mycoplasma hominis: more than just an innocent bystander”.
Journal of Antimicrobial Agents (J Antimicro). 2(2):114. doi:10.4172/2472-1212.1000114
Reply to Fournier et al. ﾓViral endocarditis or simple viral disseminated infection?
Clinical Infectious Diseases 2011. Dec;53(12):1299-300
Treatment of Chronic Hepatitis C Genotype 1 with Protease inhibitors: implications for the laboratory of molecular biology.
Noso Info. 2013, XVII (1):13-18.