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Neuroloog, neurochirurg en algoloog bundelen krachten tegen trigeminusneuralgie
Trigeminusneuralgie (TN) is een invaliderend chronisch pijnsyndroom, gekenmerkt door spontane of uitgelokte aanvallen van een zeer hevige, schietende pijn in een zone van het gelaat.
Medical mystery: abdominale klachten en krachtsvermindering (VIDEO)
Een 68-jarige man wordt opgenomen op de afdeling Maag-, Darm- en Leverziekten wegens verminderde eetlust, een opgezette buik, wisselende abdominale krampen en constipatie sinds een maand. ’s Ochtends ondervindt hij bovendien geregeld een veranderd “sponsachtig” gevoel ter hoogte van de buik. Bijkomend vermeldt hij een uitstralende pijn vanuit de heup naar de lies en later ook de lage rug. Sedert het begin van de klachten vermagerde hij een drietal kg en voelt hij zich vaak moe. Hij heeft geen koorts.
Diagnostische aanpak van patiënten met Mild Cognitive Impairment – Rol van de multidisciplinaire geheugenkliniek
Steeds meer patiënten worden verwezen voor diagnostiek en behandeling van lichte geheugenklachten. Hoewel de meeste patiënten met Mild Cognitive Impairment (MCI) een gunstige evolutie vertonen, ontwikkelt zich bij een significant aantal (18% per jaar) een dementie,doorgaans van het Alzheimertype (AD). Bovendien toont post mortemonderzoek bij MCIpatiënten vaak pathologische kenmerken van AD, zoals neurofibrillaire tangles in de hippocampus en entorhinale cortex.
Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer’s disease. Neurobiol Aging.
2021 Mar;99:100.e17-100.e23. doi: 10.1016/j.neurobiolaging.2020.09.009. Epub 2020
Diagnostic Performance of Automated MRI Volumetry by icobrain dm for Alzheimer’s Disease in a Clinical Setting: A REMEMBER Study.
J Alzheimers Dis. 2021;83(2):623-639. doi: 10.3233/JAD-210450.
Clinical variability and onset age modifiers in an extended Belgian GRN founder family.
Neurobiol Aging. 2018 Jul;67:84-94. doi: 10.1016/j.neurobiolaging.2018.03.007. Epub 2018 Mar 10.
A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis.
Acta Neurol Belg. 2018 Jun;118(2):161-168. doi: 10.1007/s13760-018-0905-0. Epub 2018 Mar 13.
Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia.
EU EOD Consortium. Neurobiol Aging. 2018 Jun;66:181.e3-181.e10. doi: 10.1016/j.neurobiolaging.2018.02.011. Epub 2018 Feb 17.
An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer’s disease.
Acta Neuropathol. 2018 Jun;135(6):827-837. doi: 10.1007/s00401-018-1841-z. Epub 2018 Mar 27
No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients.
EU EOD Consortium. Neurobiol Aging. 2018 Sep;69:293.e9-293.e11. doi: 10.1016/j.neurobiolaging.2018.05.005. Epub 2018 May 23.
Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.
EU EOD Consortium. Neurobiol Aging. 2018 Feb;62:245.e1-245.e7. doi: 10.1016/j.neurobiolaging.2017.10.012. Epub 2017 Oct 25.
A Retrospective Belgian Multi-Center MRI Biomarker Study in Alzheimer’s Disease (REMEMBER).
J Alzheimers Dis. 2018;63(4):1509-1522. doi: 10.3233/JAD-171140.
Alzheimer’s disease and driving: review of the literature and consensus guideline from Belgian dementia experts and the Belgian road safety institute endorsed by the Belgian Medical Association.
Acta Neurol Belg. 2017 Dec;117(4):811-819. doi: 10.1007/s13760-017-0840-5. Epub 2017 Oct 5. Review.
Pearls & Oy-sters: Visual agnosia: An overlooked cortical sign.
Neurology. 2016 Nov 8;87(19):e237-e238.
Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation.
Neurology. 2016 Jun 7;86(23):2126-33. doi: 10.1212/WNL.0000000000002628.
Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients.
Neurobiol Aging. 2013 Jun;34(6):1711.e1-5. DOI: 10.1016/j.neurobiolaging.2012.12.007
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.
Brain. 2016 Feb;139(Pt 2):452-67. doi: 10.1093/brain/awv358
Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.
Neurology. 2015 Dec 15;85(24):2116-25. doi: 10.1212/WNL.0000000000002220.
Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort.
Hum Mutat. 2015 Dec;36(12):1226-35. doi: 10.1002/humu.22908.
A 22-single nucleotide polymorphism Alzheimer’s disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.
Alzheimers Dement. 2015 Dec;11(12):1452-60. doi: 10.1016/j.jalz.2015.02.013.
Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.
Acta Neuropathol Commun. 2015 Nov 10;3:68. doi: 10.1186/s40478-015-0246-7.
C9orf72 repeat size correlation with onset age of disease, hypermethylation and transcriptional downregulation of the C9orf72 promoter.
Mol Psychiatry. 2015 Oct 20. doi: 10.1038/mp.2015.159
Clinical evidence for genetic anticipation in C9orf72 pedigrees.
Front. Neurosci. Published on 05 May 2015, doi:10.3389/conf.fnins.2015.89.00070
Clinical utility and applicability of biomarker-based diagnostic criteria for Alzheimer’s disease: a BeDeCo survey.
Acta Neurologica Belgica 2015, jan 10
Predictive parameters for the effect of botulinum toxin infiltrations in chronic migraine.
Toxicon 2015, 93(Suppl):S9 (January 2015)
Predictive parameters for the effect of botulinum toxin infiltrations in chronic migraine.
The Journal of Headache and Pain 2014, 15 (Suppl 1):M1 (18 September 2014)
Botulinum toxin infiltrations for chronic migraine are efficacious and safe: the Bruges experience.
Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
Investigating the role of rare heterozygous TREM2 variants in Alzheimer’s disease and frontotemporal dementia.
Neurobiol Aging. 2014 Mar;35(3):726.e11-9. Epub 2013 Oct 9. DOI: 10.1016/j.neurobiolaging.2013.09.009.
Predictive parameters for the effect of botulinum toxin infiltrations in chronic migraine.
J Headache Pain 2014;15(1):1. (abstract
Investigating the role of rare heterozygous TREM2 variants in Alzheimer’s disease and frontotemporal dementia.
Neurobiol Aging. 2014 Mar;35(3):726.e11-9. Epub 2013 Oct 9
Pseudotumoral rebound of multiple sclerosis in a pregnant patient after stopping natalizumab
Multiple sclerosis and related disorders
MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis
200-203
Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients
34(6):1711.e1-5. doi: 10.1016/j.neurobiolaging.2012.12.007
Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort
70(3):365-73. doi: 10.1001/2013.jamaneurol.181
MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis.
Multiple Sclerosis and Related Disorders 2013;2(3):200-3.
Pseudotumoral rebound of multiple sclerosis in a pregnant patient after stopping natalizumab.
Multiple Sclerosis and Related Disorders 2013. http://www.msard-journal.com/article/S2211-0348(13)00117-X/abstract
Clinical characteristics and long term prognosis in early onset multiple sclerosis.
J Neurol. 2006 Jun;253(6):720-3. Epub 2006 Mar 6.